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- Title
Organ-on-chip applications in drug discovery: an end user perspective.
- Authors
Clapp, Naomi; Amour, Augustin; Rowan, Wendy C.; Candarlioglu, Pelin L.
- Abstract
Organ-on-chip (OoC) systems are in vitro microfluidic models that mimic the microstructures, functions and physiochemical environments of whole living organs more accurately than two-dimensional models. While still in their infancy, OoCs are expected to bring ground-breaking benefits to a myriad of applications, enabling more human-relevant candidate drug efficacy and toxicity studies, and providing greater insights into mechanisms of human disease. Here, we explore a selection of applications of OoC systems. The future directions and scope of implementing OoCs across the drug discovery process are also discussed.
- Subjects
DRUG efficacy; DRUG toxicity; TWO-dimensional models; INFANTS; DRUGS
- Publication
Biochemical Society Transactions, 2021, Vol 49, Issue 4, p1881
- ISSN
0300-5127
- Publication type
Article
- DOI
10.1042/BST20210840