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- Title
Impaired Metabolic Flexibility to High-Fat Overfeeding Predicts Future Weight Gain in Healthy Adults.
- Authors
Begaye, Brittany; Vinales, Karyne L.; Hollstein, Tim; Takafumi Ando; Walter, Mary; Bogardus, Clifton; Krakoff, Jonathan; Piaggi, Paolo; Ando, Takafumi
- Abstract
The ability to switch fuels for oxidation in response to changes in macronutrient composition of diet (metabolic flexibility) may be informative of individuals' susceptibility to weight gain. Seventy-nine healthy, weight-stable participants underwent 24-h assessments of energy expenditure and respiratory quotient (RQ) in a whole-room calorimeter during energy balance (EBL) (50% carbohydrate, 30% fat) and then during 24-h fasting and three 200% overfeeding diets in a crossover design. Metabolic flexibility was defined as the change in 24-h RQ from EBL during fasting and standard overfeeding (STOF) (50% carbohydrate, 30% fat), high-fat overfeeding (HFOF) (60% fat, 20% carbohydrate), and high-carbohydrate overfeeding (HCOF) (75% carbohydrate, 5% fat) diets. Free-living weight change was assessed after 6 and 12 months. Compared with EBL, RQ decreased on average by 9% during fasting and by 4% during HFOF but increased by 4% during STOF and by 8% during HCOF. A smaller decrease in RQ, reflecting a smaller increase in lipid oxidation rate, during HFOF but not during the other diets predicted greater weight gain at both 6 and 12 months. An impaired metabolic flexibility to acute HFOF can identify individuals prone to weight gain, indicating that an individual's capacity to oxidize dietary fat is a metabolic determinant of weight change.
- Subjects
WEIGHT gain; FUEL switching; RESPIRATORY quotient; CARBOHYDRATES; FAT; ENERGY metabolism; FASTING; RESEARCH; FAT content of food; RESEARCH methodology; CARBOHYDRATE content of food; EVALUATION research; MEDICAL cooperation; COMPARATIVE studies
- Publication
Diabetes, 2020, Vol 69, Issue 2, p181
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/db19-0719