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- Title
Quassinoids from Twigs of Harrisonia perforata (Blanco) Merr and Their Anti-Parkinson's Disease Effect.
- Authors
Cai, Min; Bai, Xiao-Lin; Zang, Hao-Jing; Tang, Xiao-Han; Yan, Ying; Wan, Jia-Jia; Peng, Min-You; Liang, Hong; Liu, Lin; Guo, Feng; Zhao, Pei-Ji; Liao, Xun; Di, Ying-Tong; Hao, Xiao-Jiang
- Abstract
Six new C-20 and one new C-19 quassinoids, named perforalactones F-L (1–7), were isolated from twigs of Harrisonia perforata. Spectroscopic and X-ray crystallographic experiments were conducted to identify their structures. Through oxidative degradation of perforalactone B to perforaqussin A, the biogenetic process from C-25 quassinoid to C-20 via Baeyer–Villiger oxidation was proposed. Furthermore, the study evaluated the anti-Parkinson's disease potential of these C-20 quassinoids for the first time on 6-OHDA-induced PC12 cells and a Drosophila Parkinson's disease model of PINK1B9. Perforalactones G and I (2 and 4) showed a 10–15% increase in cell viability of the model cells at 50 μM, while compounds 2 and 4 (100 μM) significantly improved the climbing ability of PINK1B9 flies and increased the dopamine level in the brains and ATP content in the thoraces of the flies.
- Subjects
TWIGS; BAEYER-Villiger rearrangement; DOPAMINE receptors; PARKINSON'S disease
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 22, p16196
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms242216196