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- Title
The SARS-CoV-2 Delta-Omicron Recombinant Lineage (XD) Exhibits Immune-Escape Properties Similar to the Omicron (BA.1) Variant.
- Authors
Arora, Prerna; Zhang, Lu; Rocha, Cheila; Graichen, Luise; Nehlmeier, Inga; Kempf, Amy; Cossmann, Anne; Ramos, Gema Morillas; Baier, Eva; Tampe, Björn; Moerer, Onnen; Dickel, Steffen; Winkler, Martin S.; Behrens, Georg M. N.; Pöhlmann, Stefan; Hoffmann, Markus
- Abstract
Recently, a recombinant SARS-CoV-2 lineage, XD, emerged that harbors a spike gene that is largely derived from the Omicron variant BA.1 in the genetic background of the Delta variant. This finding raised concerns that the recombinant virus might exhibit altered biological properties as compared to the parental viruses and might pose an elevated threat to human health. Here, using pseudotyped particles, we show that ACE2 binding and cell tropism of XD mimics that of BA.1. Further, XD and BA.1 displayed comparable sensitivity to neutralization by antibodies induced upon vaccination with BNT162b2/Comirnaty (BNT) or BNT vaccination followed by breakthrough infection. Our findings reveal important biological commonalities between XD and Omicron BA.1 host cell entry and its inhibition by antibodies.
- Subjects
SARS-CoV-2 Omicron variant; SARS-CoV-2 Delta variant; SARS-CoV-2; RECOMBINANT viruses; BREAKTHROUGH infections; VIRAL tropism
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 22, p14057
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms232214057