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- Title
MicroRNAs: Important Regulatory Molecules in Acute Lung Injury/Acute Respiratory Distress Syndrome.
- Authors
Lu, Qianying; Yu, Sifan; Meng, Xiangyan; Shi, Mingyu; Huang, Siyu; Li, Junfeng; Zhang, Jianfeng; Liang, Yangfan; Ji, Mengjun; Zhao, Yanmei; Fan, Haojun
- Abstract
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is an overactivated inflammatory response caused by direct or indirect injuries that destroy lung parenchymal cells and dramatically reduce lung function. Although some research progress has been made in recent years, the pathogenesis of ALI/ARDS remains unclear due to its heterogeneity and etiology. MicroRNAs (miRNAs), a type of small noncoding RNA, play a vital role in various diseases. In ALI/ARDS, miRNAs can regulate inflammatory and immune responses by targeting specific molecules. Regulation of miRNA expression can reduce damage and promote the recovery of ALI/ARDS. Consequently, miRNAs are considered as potential diagnostic indicators and therapeutic targets of ALI/ARDS. Given that inflammation plays an important role in the pathogenesis of ALI/ARDS, we review the miRNAs involved in the inflammatory process of ALI/ARDS to provide new ideas for the pathogenesis, clinical diagnosis, and treatment of ALI/ARDS.
- Subjects
ADULT respiratory distress syndrome; LUNGS; LINCRNA; RESPIRATORY distress syndrome; LUNG injuries; MICRORNA; NON-coding RNA
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 10, p5545
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms23105545