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- Title
Novel Strategies for Spinal Cord Regeneration.
- Authors
Costăchescu, Bogdan; Niculescu, Adelina-Gabriela; Dabija, Marius Gabriel; Teleanu, Raluca Ioana; Grumezescu, Alexandru Mihai; Eva, Lucian
- Abstract
A spinal cord injury (SCI) is one of the most devastating lesions, as it can damage the continuity and conductivity of the central nervous system, resulting in complex pathophysiology. Encouraged by the advances in nanotechnology, stem cell biology, and materials science, researchers have proposed various interdisciplinary approaches for spinal cord regeneration. In this respect, the present review aims to explore the most recent developments in SCI treatment and spinal cord repair. Specifically, it briefly describes the characteristics of SCIs, followed by an extensive discussion on newly developed nanocarriers (e.g., metal-based, polymer-based, liposomes) for spinal cord delivery, relevant biomolecules (e.g., growth factors, exosomes) for SCI treatment, innovative cell therapies, and novel natural and synthetic biomaterial scaffolds for spinal cord regeneration.
- Subjects
SPINAL cord; CYTOLOGY; NERVOUS system regeneration; REGENERATION (Biology); SPINAL cord injuries
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 9, p4552
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms23094552