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- Title
MHC Class I Deficiency in Solid Tumors and Therapeutic Strategies to Overcome It.
- Authors
Shklovskaya, Elena; Rizos, Helen
- Abstract
It is now well accepted that the immune system can control cancer growth. However, tumors escape immune-mediated control through multiple mechanisms and the downregulation or loss of major histocompatibility class (MHC)-I molecules is a common immune escape mechanism in many cancers. MHC-I molecules present antigenic peptides to cytotoxic T cells, and MHC-I loss can render tumor cells invisible to the immune system. In this review, we examine the dysregulation of MHC-I expression in cancer, explore the nature of MHC-I-bound antigenic peptides recognized by immune cells, and discuss therapeutic strategies that can be used to overcome MHC-I deficiency in solid tumors, with a focus on the role of natural killer (NK) cells and CD4 T cells.
- Subjects
CYTOTOXIC T cells; TUMOR growth; T cells; IMMUNE system; IMMUNE checkpoint proteins
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 13, p6741
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22136741