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- Title
Molecular Imaging of Apoptosis: The Case of Caspase-3 Radiotracers.
- Authors
Beroske, Lucas; Van den Wyngaert, Tim; Stroobants, Sigrid; Van der Veken, Pieter; Elvas, Filipe
- Abstract
The molecular imaging of apoptosis remains an important method for the diagnosis and monitoring of the progression of certain diseases and the evaluation of the efficacy of anticancer apoptosis-inducing therapies. Among the multiple biomarkers involved in apoptosis, activated caspase-3 is an attractive target, as it is the most abundant of the executioner caspases. Nuclear imaging is a good candidate, as it combines a high depth of tissue penetration and high sensitivity, features necessary to detect small changes in levels of apoptosis. However, designing a caspase-3 radiotracer comes with challenges, such as selectivity, cell permeability and transient caspase-3 activation. In this review, we discuss the different caspase-3 radiotracers for the imaging of apoptosis together with the challenges of the translation of various apoptosis-imaging strategies in clinical trials.
- Subjects
RADIOACTIVE tracers; CASPASES; SINGLE-photon emission computed tomography; CELL permeability
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 8, p3948
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22083948