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- Title
Advances in Lupus Nephritis Pathogenesis: From Bench to Bedside.
- Authors
Obrișcă, Bogdan; Sorohan, Bogdan; Tuță, Liliana; Ismail, Gener; Kurien, Biji Theyilamannil
- Abstract
Systemic lupus erythematosus (SLE) is the prototype of autoimmune disorders caused by a loss of tolerance to endogenous nuclear antigens triggering an aberrant autoimmune response targeting various tissues. Lupus nephritis (LN), a major cause of morbidity and mortality in patients with SLE, affects up to 60% of patients. The recent insights into the genetic and molecular basis of SLE and LN paved the way for newer therapies to be developed for these patients. Apart from the traditional B-cell-centered view of this disease pathogenesis, acknowledging that multiple extrarenal and intrarenal pathways contribute to kidney-specific autoimmunity and injury may help refine the individual therapeutic and prognostic characterization of such patients. Accordingly, the formerly induction-maintenance treatment strategy was recently challenged with the exciting results obtained from the trials that evaluated add-on therapy with voclosporin, belimumab, or Obinutuzumab. The scope of this review is to provide an insight into the current knowledge of LN pathogenesis and future therapeutic strategies.
- Subjects
LUPUS nephritis; SYSTEMIC lupus erythematosus
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 7, p3766
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22073766