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- Title
Oenanthe Javanica Extract Protects Mouse Skin from UVB Radiation via Attenuating Collagen Disruption and Inflammation.
- Authors
Her, Young; Shin, Bich-Na; Lee, Yun Lyul; Park, Joon Ha; Ahn, Ji Hyeon; Kim, Dae Won; Kim, Ki Seob; Kim, Hyunjung; Song, Minah; Kim, Jong-Dai; Won, Moo-Ho
- Abstract
In recent years, the use of botanical agents to prevent skin damage from solar ultraviolet (UV) irradiation has received considerable attention. Oenanthe javanica is known to exert anti-inflammatory and antioxidant activities. This study investigated photoprotective properties of an Oenanthe javanica extract (OJE) against UVB-induced skin damage in ICR mice. The extent of skin damage was evaluated in three groups: control mice with no UVB, UVB-exposed mice treated with vehicle (saline), and UVB-exposed mice treated with 1% extract. Photoprotective properties were assessed in the dorsal skin using hematoxylin and eosin staining, Masson trichrome staining, immunohistochemical staining, quantitative real-time polymerase chain reaction, and western blotting to analyze the epidermal thickness, collagen expression, and mRNA and protein levels of type I collagen, type III collagen, and interstitial collagenases, including matrix metalloproteinase (MMP)-1 and MMP-3. In addition, tumor necrosis factor (TNF)-α and cyclooxygenase (COX)-2 protein levels were also assessed. In the UVB-exposed mice treated with extract, UV-induced epidermal damage was significantly ameliorated. In this group, productions of collagen types I and III were increased, and expressions of MMP-1 and MMP-3 were decreased. In addition, TNF-α and COX-2 expressions were reduced. Based on these findings, we conclude that OJE displays photoprotective effects against UVB-induced collagen disruption and inflammation and suggest that Oenanthe javanica can be used as a natural product for the treatment of photodamaged skin.
- Subjects
SKIN inflammation; SKIN aging; PHYSIOLOGICAL effects of ultraviolet radiation; TELANGIECTASIA; DERMIS; MATRIX metalloproteinases; HYPERPIGMENTATION
- Publication
International Journal of Molecular Sciences, 2019, Vol 20, Issue 6, p1435
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms20061435