We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Evaluation of Hepatic Tissue Blood Flow Using Xenon Computed Tomography with Fibrosis Progression in Nonalcoholic Fatty Liver Disease: Comparison with Chronic Hepatitis C.
- Authors
Ryuta Shigefuku; Hideaki Takahashi; Masaki Kato; Yoshihito Yoshida; Keigo Suetani; Yohei Noguchi; Moriaki Hatsugai; Kazunari Nakahara; Hiroki Ikeda; Minoru Kobayashi; Kotaro Matsunaga; Nobuyuki Matsumoto; Chiaki Okuse; Fumio Itoh; Shiro Maeyama; Shigeru Sase; Michihiro Suzuki
- Abstract
Aims: The present study evaluated the utility of xenon computed tomography (Xe-CT) as a noninvasive diagnostic procedure for the measurement of hepatic tissue blood flow (TBF) in patients with nonalcoholic fatty liver disease (NAFLD) or chronic hepatitis C (CH-C). Methods: Xe-CT was performed in 93 patients with NAFLD and in 109 patients with CH-C. Subjects were classified into one of three groups, based on fibrosis stage: group 1, no bridging fibrosis; group 2, bridging fibrosis; and group 3, liver cirrhosis. Correlations between hepatic TBFs in each fibrosis stage were examined. Results: In group 1, portal venous TBF (PVTBF), hepatic arterial (HATBF), and total hepatic TBF (THTBF) were significantly lower in patients with in nonalcoholic steatohepatitis (NASH) than in those with CH-C (p < 0.001, p < 0.05, p < 0.001, respectively). In group 2, PVTBF and THTBF were significantly lower in patients with in NASH than in those with CH-C (p < 0.001, p < 0.05, respectively). In group 3, hepatic TBFs were not significantly different when comparing patients with NASH and those with CH-C. Conclusions: PVTBF decreased due to fat infiltration. Therefore, hemodynamic changes occur relatively earlier in NAFLD than in CH-C. Patients with NASH should be monitored carefully for portal hypertensive complications in the early fibrosis stage.
- Subjects
XENON; COMPUTED tomography; FATTY liver; RENAL fibrosis; BLOOD flow; HEPATITIS C; DISEASE progression
- Publication
International Journal of Molecular Sciences, 2014, Vol 15, Issue 1, p1026
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms15011026