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- Title
The application of composite scaffold materials based on decellularized vascular matrix in tissue engineering: a review.
- Authors
Li, Jingying; Chen, Xiao; Hu, Miaoling; Wei, Jian; Nie, Minhai; Chen, Jiana; Liu, Xuqian
- Abstract
Decellularized vascular matrix is a natural polymeric biomaterial that comes from arteries or veins which are removed the cellular contents by physical, chemical and enzymatic means, leaving only the cytoskeletal structure and extracellular matrix to achieve cell adhesion, proliferation and differentiation and creating a suitable microenvironment for their growth. In recent years, the decellularized vascular matrix has attracted much attention in the field of tissue repair and regenerative medicine due to its remarkable cytocompatibility, biodegradability and ability to induce tissue regeneration. Firstly, this review introduces its basic properties and preparation methods; then, it focuses on the application and research of composite scaffold materials based on decellularized vascular matrix in vascular tissue engineering in terms of current in vitro and in vivo studies, and briefly outlines its applications in other tissue engineering fields; finally, it looks into the advantages and drawbacks to be overcome in the application of decellularized vascular matrix materials. In conclusion, as a new bioactive material for building engineered tissue and repairing tissue defects, decellularized vascular matrix will be widely applied in prospect.
- Subjects
TISSUE scaffolds; TISSUE engineering; COMPOSITE materials; REGENERATIVE medicine; CELL adhesion; EXTRACELLULAR matrix; CONSTRUCTION materials
- Publication
BioMedical Engineering OnLine, 2023, Vol 22, Issue 1, p1
- ISSN
1475-925X
- Publication type
Article
- DOI
10.1186/s12938-023-01120-z