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- Title
Copper-Catalyzed Cascade Cyclization for the Synthesis of Trifluoromethyl-Substituted Spiro-2 H-azirines from 1,6-Enynes.
- Authors
He, Yu ‐ Tao; Wang, Qiang; Zhao, Jiahui; Wang, Xiao ‐ Zhen; Qiu, Yi ‐ Feng; Yang, Yu ‐ Chen; Hu, Jing ‐ Yuan; Liu, Xue ‐ Yuan; Liang, Yong ‐ Min
- Abstract
A method for the synthesis of trifluoromethyl CF3-substituted spirocyclic compounds containing with a unique quaternary carbon center from readily available starting materials has been developed. The reaction provides a facile access to 2 H-azirines via cascade cyclization. These compounds constitute a new class of functionalized synthetic intermediates, which can be used for the synthesis of various nitrogen-containing heterocycles and biologically active CF3-containing compounds.
- Subjects
RING formation (Chemistry); AZIRINES; COPPER catalysts; HETEROCYCLIC compounds synthesis; ENYNES
- Publication
Advanced Synthesis & Catalysis, 2015, Vol 357, Issue 14/15, p3069
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201500510