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- Title
MRI of transplanted pancreatic islets.
- Authors
Jirák, Daniel; Kríz, Jan; Herynek, Vít; Andersson, Benita; Girman, Peter; Burian, Martin; Saudek, František; Hájek, Milan
- Abstract
A promising treatment method for type 1 diabetes mellitus is transplantation of pancreatic islets containing β-cells. The aim of this study was to develop an MR technique to monitor the distribution and fate of transplanted pancreatic islets in an animal model. Twenty-five hundred purified and magnetically labeled islets were transplanted through the portal vein into the liver of experimental rats. The animals were scanned using a MR 4.7-T scanner. The labeled pancreatic islets were clearly visualized in the liver in both diabetic and healthy rats as hypointense areas on T2*-weighted MR images during the entire measurement period. Transmission electron microscopy confirmed the presence of iron-oxide nanoparticles inside the cells of the pancreatic islets. A significant decrease in blood glucose levels in diabetic rats was observed; normal glycemia was reached 1 week after transplantation. This study, therefore, represents a promising step toward possible clinical application in human medicine. Magn Reson Med 52:1228-1233, 2004. © 2004 Wiley-Liss, Inc.
- Publication
Magnetic Resonance in Medicine, 2004, Vol 52, Issue 6, p1228
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.20282