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- Title
Three New Medicagenic Acid Saponins from Polygala micrantha.
- Authors
Tabopda, Turibio Kuiate; Mitaine-Offer, Anne-Claire; Miyamoto, Tomofumi; Tanaka, Chiaki; Ngadjui, Bonaventure Tchaleu; Mirjolet, Jean-François; Duchamp, Olivier; Lacaille-Dubois, Marie-Aleth
- Abstract
Three new medicagenic acid saponins, micranthosides A-C (-), were isolated from the roots of Polygala micrantha . & ., along with six known presenegenin saponins. Their structures were elucidated on the basis of extensive 1D- and 2D-NMR experiments (H, C, DEPT, COSY, TOCSY, NOESY, HSQC, and HMBC) and mass spectrometry as 3- O- β--glucopyranosylmedicagenic acid 28-[ O- β--galactopyranosyl-(1→4)- O- β--xylopyranosyl-(1→4)- O- α--rhamnopyranosyl-(1→2)- β--fucopyranosyl] ester (), 3- O- β--glucopyranosylmedicagenic acid 28-[ O-6- O-acetyl- β--galactopyranosyl-(1→4)- O- β--xylopyranosyl-(1→4)- O- α--rhamnopyranosyl-(1→2)- β--fucopyranosyl] ester (), and 3- O-{ O- β--glucopyranosyl-(1→3)- O-[ β--glucopyranosyl-(1→6)]- β--glucopyranosyl}medicagenic acid 28-{ O- β--apiofuranosyl-(1→3)- O- β--xylopyranosyl-(1→4)- O-[ β--apiofuranosyl-(1→3)]- O- α--rhamnopyranosyl-(1→2)- β--fucopyranosyl} ester (). Compounds - were evaluated against HCT 116 and HT-29 human colon cancer cells, but they did not show any cytotoxicity.
- Subjects
SAPONINS; POLYGALA; ACIDS; CANCER cells; COLON cancer
- Publication
Helvetica Chimica Acta, 2011, Vol 94, Issue 5, p914
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201000331