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- Title
RNA-guided genetic silencing systems in bacteria and archaea.
- Authors
Wiedenheft, Blake; Sternberg, Samuel H.; Doudna, Jennifer A.
- Abstract
Clustered regularly interspaced short palindromic repeat (CRISPR) are essential components of nucleic-acid-based adaptive immune systems that are widespread in bacteria and archaea. Similar to RNA interference (RNAi) pathways in eukaryotes, CRISPR-mediated immune systems rely on small RNAs for sequence-specific detection and silencing of foreign nucleic acids, including viruses and plasmids. However, the mechanism of RNA-based bacterial immunity is distinct from RNAi. Understanding how small RNAs are used to find and destroy foreign nucleic acids will provide new insights into the diverse mechanisms of RNA-controlled genetic silencing systems.
- Subjects
BACTERIAL inactivation; ARCHAEBACTERIA; EUKARYOTES; VIRAL disease treatment; PLASMID genetics; IMMUNE system
- Publication
Nature, 2012, Vol 482, Issue 7385, p331
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature10886