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- Title
Synthesis of diverse 4,5-dihydro-3(2 H)-pyridazinones on Wang resin.
- Authors
Gouault, N.; Cupif, J. F.; Picard, S.; Lecat, A.; David, M.
- Abstract
An efficient solid-phase synthesis of structurally diverse 4,5-dihydro-3(2 H)-pyridazinones is described using readily available substituted 4-oxo-butanoic acids. Polymer-supported γ-keto-esters prepared from Wang resin reacted with several hydrazines to afford the corresponding hydrazones. A protocol developed in mild conditions without isolating the intermediate hydrazone led to pyridazinones in good yields after a cyclization cleavage approach. This successful strategy represents an attractive method for a rapid synthesis of heterocyclic libraries for biological evaluation.
- Publication
Journal of Pharmacy & Pharmacology, 2001, Vol 53, Issue 7, p981
- ISSN
0022-3573
- Publication type
Article
- DOI
10.1211/0022357011776225