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- Title
G1m1 predominance of intrathecal virus‐specific antibodies in multiple sclerosis.
- Authors
Tomescu‐Baciu, Alina; Vartdal, Frode; Lossius, Andreas; Holmøy, Trygve; Vedeler, Christian A.
- Abstract
We have previously shown that plasmablasts of the G1m1 allotype of IgG1 are selectively enriched in the cerebrospinal fluid of G1m1/G1m3 heterozygous patients with multiple sclerosis, whereas both allotypes are equally used in neuroborreliosis. Here, we demonstrate a strong preference for the G1m1 allotype in the intrathecal humoral immune responses against measles, rubella, and varicella zoster virus in G1m1/G1m3 heterozygous multiple sclerosis patients. Conversely, intrathecally synthesized varicella zoster virus‐specific IgG1 in varicella zoster virus meningoencephalitis comprised both allotypes. This implies that G1m1 B cells are selected to the central nervous system of multiple sclerosis patients regardless of specificity and suggests that an antigen‐independent mechanism could drive the intrathecal humoral immune response.
- Subjects
MULTIPLE sclerosis; CEREBROSPINAL fluid; IMMUNOGLOBULIN allotypes; CD20 antigen; VARICELLA-zoster virus
- Publication
Annals of Clinical & Translational Neurology, 2018, Vol 5, Issue 10, p1303
- ISSN
2328-9503
- Publication type
Article
- DOI
10.1002/acn3.642