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- Title
Analysis of particulate exposure during continuous drug infusion in critically ill adult patients: a preliminary proof-of-concept in vitro study.
- Authors
Benlabed, Malik; Martin Mena, Anthony; Gaudy, Romain; Perez, Maxime; Genay, Stéphanie; Hecq, Jean-Daniel; Odou, Pascal; Lebuffe, Gilles; Décaudin, Bertrand
- Abstract
Background: In critically ill patients, drug incompatibilities frequently occur because of the number of drugs to be administered through a limited number of infusion lines. These are among the main causes of particulate contamination. However, little data is available to quantify particle exposure during simultaneous IV-drug infusion. The objective of this study was to evaluate the particulate matter potentially administered to critically ill patients.Methods: The particulate matter (between 1 μm and 30 mm) of infused therapies used in ICUs for patients suffering from either septic shock or acute respiratory distress syndrome was measured in vitro over 6 h using a dynamic image analysis device, so that both overall particulate contamination and particle sizes could be determined. Data is presented according to the recommendations of the European Pharmacopoeia (≥ 10 and 25 μm).Results: For the six experimental procedures (continuous infusion of norepinephrine, midazolam, sufentanil, heparin, 5% glucose, binary parenteral nutrition and discontinuous administrations of omeprazole, piperacillin/tazobactam and fluconazole), the overall number of particles over the 6-h infusion period was 8256 [5013; 15,044]. The collected values for the number of particles ≥ 10 and 25 μm were 281 [118; 526] and 19 [7; 96] respectively. Our results showed that discontinuous administrations of drugs led to disturbances in particulate contamination.Conclusions: This work indicates the amount of particulate matter potentially administered to critically ill adult patients. Particulate contamination appears lower than previous measurements performed during multidrug IV therapies in children.
- Subjects
DRUG infusion pumps; CRITICALLY ill patient care; INCOMPATIBLES (Pharmacy); IMAGE analysis; ADULT respiratory distress syndrome
- Publication
Intensive Care Medicine Experimental, 2018, Vol 6, Issue 1, p1
- ISSN
2197-425X
- Publication type
Article
- DOI
10.1186/s40635-018-0205-2