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- Title
Metagenomic Sequencing of an Echovirus 30 Genome From Cerebrospinal Fluid of a Patient With Aseptic Meningitis and Orchitis.
- Authors
Piantadosi, Anne; Mukerji, Shibani S.; Chitneni, Pooja; Cho, Tracey A.; Cosimi, Lisa A.; Hung, Deborah T.; Goldberg, Marcia B.; Sabeti, Pardis C.; Kuritzkes, Daniel R.; Grad, Yonatan H.
- Abstract
Enteroviruses cause a wide spectrum of clinical disease. In this study, we describe the case of a young man with orchitis and aseptic meningitis who was diagnosed with enterovirus infection. Using unbiased "metagenomic" massively parallel sequencing, we assembled a near-complete viral genome, the first use of this method for full-genome viral sequencing from cerebrospinal fluid. We found that the genome belonged to the subgroup echovirus 30, which is a common cause of aseptic meningitis but has not been previously reported to cause orchitis.
- Subjects
ENTEROVIRUSES; MENINGITIS; METAGENOMICS; PATIENTS
- Publication
Open Forum Infectious Diseases, 2017, Vol 4, Issue 3, p1
- ISSN
2328-8957
- Publication type
Case Study
- DOI
10.1093/ofid/ofx138