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- Title
Prescription preferences of antiepileptic drugs in brain tumor patients: An international survey among EANO members.
- Authors
Meer, Pim B van der; Dirven, Linda; Bent, Martin J van den; Preusser, Matthias; Taphoorn, Martin J B; Rudá, Roberta; Koekkoek, Johan A F
- Abstract
Background This study aimed at investigating antiepileptic drug (AED) prescription preferences in patients with brain tumor-related epilepsy (BTRE) among the European neuro-oncology community, the considerations that play a role when initiating AED treatment, the organization of care, and practices with regard to AED withdrawal. Methods A digital survey containing 31 questions about prescription preferences of AEDs was set out among members of the European Association of Neuro-Oncology (EANO). Results A total of 198 respondents treating patients with BTRE participated of whom 179 completed the entire survey. Levetiracetam was the first choice in patients with BTRE for almost all respondents (90% [162/181]). Levetiracetam was considered the most effective AED in reducing seizure frequency (72% [131/181]) and having the least adverse effects (48% [87/181]). Common alternatives for levetiracetam as equivalent first choice included lacosamide (33% [59/181]), lamotrigine (22% [40/181]), and valproic acid (21% [38/181]). Most crucial factors to choose a specific AED were potential adverse effects (82% [148/181]) and interactions with antitumor treatments (76% [137/181]). In the majority of patients, neuro-oncologists were involved in the treatment of seizures (73% [132/181])). Other relevant findings were that a minority of respondents ever prescribe AEDs in brain tumor patients without epilepsy solely as prophylaxis (29% [53/181]), but a majority routinely considers complete AED withdrawal in BTRE patients who are seizure-free after antitumor treatment (79% [141/179]). Conclusions Our results show that among European professionals treating patients with BTRE levetiracetam is considered the first choice AED, with the presumed highest efficacy and least adverse effects.
- Subjects
ANTICONVULSANTS; BRAIN tumors; VALPROIC acid; PATIENT surveys; LEVETIRACETAM
- Publication
Neuro-Oncology Practice, 2022, Vol 9, Issue 2, p105
- ISSN
2054-2577
- Publication type
Article
- DOI
10.1093/nop/npab059