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Enhanced detection of expanded repeat mRNA foci with hybridization chain reaction.
Published in:
Acta Neuropathologica Communications, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40478-021-01169-8
By:
- Glineburg, M. Rebecca;
- Zhang, Yuan;
- Krans, Amy;
- Tank, Elizabeth M.;
- Barmada, Sami J.;
- Todd, Peter K.
Publication type:
Article
The carboxyl termini of RAN translated GGGGCC nucleotide repeat expansions modulate toxicity in models of ALS/FTD.
Published in:
Acta Neuropathologica Communications, 2020, v. 8, n. 1, p. 1, doi. 10.1186/s40478-020-01002-8
By:
- He, Fang;
- Flores, Brittany N.;
- Krans, Amy;
- Frazer, Michelle;
- Natla, Sam;
- Niraula, Sarjina;
- Adefioye, Olamide;
- Barmada, Sami J.;
- Todd, Peter K.
Publication type:
Article
Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-12191-8
By:
- François-Moutal, Liberty;
- Scott, David Donald;
- Ambrose, Andrew J.;
- Zerio, Christopher J.;
- Rodriguez-Sanchez, Marina;
- Dissanayake, Kumara;
- May, Danielle G.;
- Carlson, Jacob M.;
- Barbieri, Edward;
- Moutal, Aubin;
- Roux, Kyle J.;
- Shorter, James;
- Khanna, Rajesh;
- Barmada, Sami J.;
- McGurk, Leeanne;
- Khanna, May
Publication type:
Article
Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30387-4
By:
- Krishnan, Gopinath;
- Raitcheva, Denitza;
- Bartlett, Daniel;
- Prudencio, Mercedes;
- McKenna-Yasek, Diane M.;
- Douthwright, Catherine;
- Oskarsson, Björn E.;
- Ladha, Shafeeq;
- King, Oliver D.;
- Barmada, Sami J.;
- Miller, Timothy M.;
- Bowser, Robert;
- Watts, Jonathan K.;
- Petrucelli, Leonard;
- Brown, Robert H.;
- Kankel, Mark W.;
- Gao, Fen-Biao
Publication type:
Article
The MLO-down on TDP-43.
Published in:
Brain: A Journal of Neurology, 2023, v. 146, n. 9, p. 3565, doi. 10.1093/brain/awad268
By:
- Dykstra, Megan;
- Barmada, Sami J
Publication type:
Article
TDP-43 stabilizes G3BP1 mRNA: relevance to amyotrophic lateral sclerosis/frontotemporal dementia.
Published in:
2021
By:
- Sidibé, Hadjara;
- Khalfallah, Yousra;
- Xiao, Shangxi;
- Gómez, Nicolás B;
- Fakim, Hana;
- Tank, Elizabeth M H;
- Tomasso, Geneviève Di;
- Bareke, Eric;
- Aulas, Anaïs;
- McKeever, Paul M;
- Melamed, Ze'ev;
- Destroimaisons, Laurie;
- Deshaies, Jade-Emmanuelle;
- Zinman, Lorne;
- Parker, J Alex;
- Legault, Pascale;
- Tétreault, Martine;
- Barmada, Sami J;
- Robertson, Janice;
- Velde, Christine Vande
Publication type:
journal article
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 3, p. 981, doi. 10.1172/JCI72723
By:
- Haiyan Qiu;
- Sebum Lee;
- Yulei Shang;
- Wen-Yuan Wang;
- Kin Fai Au;
- Kamiya, Sherry;
- Barmada, Sami J.;
- Finkbeiner, Steven;
- Lui, Hansen;
- Carlton, Caitlin E.;
- Tang, Amy A.;
- Oldham, Michael C.;
- Hejia Wang;
- Shorter, James;
- Filiano, Anthony J.;
- Roberson, Erik D.;
- Tourtellotte, Warren G.;
- Bin Chen;
- Li-Huei Tsai;
- Huang, Eric J.
Publication type:
Article
Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.
Published in:
2012
By:
- Martens LH;
- Zhang J;
- Barmada SJ;
- Zhou P;
- Kamiya S;
- Sun B;
- Min SW;
- Gan L;
- Finkbeiner S;
- Huang EJ;
- Farese RV Jr;
- Martens, Lauren Herl;
- Zhang, Jiasheng;
- Barmada, Sami J;
- Zhou, Ping;
- Kamiya, Sherry;
- Sun, Binggui;
- Min, Sang-Won;
- Gan, Li;
- Finkbeiner, Steven
Publication type:
journal article
Progranulin deficienc y promotes neuroinflammation and neuron loss following toxin-induced injury.
Published in:
Journal of Clinical Investigation, 2012, v. 122, n. 11, p. 3955, doi. 10.1172/JCI63113
By:
- Martens, Lauren Herl;
- Jiasheng Zhang;
- Barmada, Sami J.;
- Ping Zhou;
- Kamiya, Sherry;
- Binggui Sun;
- Sang-Won Min;
- Li Gan;
- Finkbeiner, Steven;
- Huang, Eric J.;
- Farese, Robert V.
Publication type:
Article
Ubiquilin-2 regulates pathological alpha-synuclein.
Published in:
Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-022-26899-0
By:
- Sandoval-Pistorius, Stephanie S.;
- Gerson, Julia E.;
- Liggans, Nyjerus;
- Ryou, Jaimie H.;
- Oak, Kulin;
- Li, Xingli;
- Negron-Rios, Keyshla Y.;
- Fischer, Svetlana;
- Barsh, Henry;
- Crowley, Emily V.;
- Skinner, Mary E.;
- Sharkey, Lisa M.;
- Barmada, Sami J.;
- Paulson, Henry L.
Publication type:
Article
Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-12191-8
By:
- François-Moutal, Liberty;
- Scott, David Donald;
- Ambrose, Andrew J.;
- Zerio, Christopher J.;
- Rodriguez-Sanchez, Marina;
- Dissanayake, Kumara;
- May, Danielle G.;
- Carlson, Jacob M.;
- Barbieri, Edward;
- Moutal, Aubin;
- Roux, Kyle J.;
- Shorter, James;
- Khanna, Rajesh;
- Barmada, Sami J.;
- McGurk, Leeanne;
- Khanna, May
Publication type:
Article
Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models.
Published in:
Nature Genetics, 2012, v. 44, n. 12, p. 1302, doi. 10.1038/ng.2434
By:
- Armakola, Maria;
- Higgins, Matthew J;
- Figley, Matthew D;
- Barmada, Sami J;
- Scarborough, Emily A;
- Diaz, Zamia;
- Fang, Xiaodong;
- Shorter, James;
- Krogan, Nevan J;
- Finkbeiner, Steven;
- Farese, Robert V;
- Gitler, Aaron D
Publication type:
Article
Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis.
Published in:
PLoS Genetics, 2017, v. 13, n. 5, p. 1, doi. 10.1371/journal.pgen.1006805
By:
- Park, Sei-Kyoung;
- Hong, Joo Y.;
- Arslan, Fatih;
- Kanneganti, Vydehi;
- Patel, Basant;
- Tietsort, Alex;
- Tank, Elizabeth M. H.;
- Li, Xingli;
- Barmada, Sami J.;
- Liebman, Susan W.
Publication type:
Article
Transgene-coded chimeric proteins as reporters of intracellular proteolysis: Starvation-induced catabolism of a lacZ fusion protein in muscle cells of Caenorhabditis elegans.
Published in:
Journal of Cellular Biochemistry, 1997, v. 67, n. 1, p. 143, doi. 10.1002/(SICI)1097-4644(19971001)67:1<143::AID-JCB15>3.0.CO;2-I
By:
- Zdinak, Lisa A.;
- Greenberg, Ian B.;
- Szewczyk, Nathaniel J.;
- Barmada, Sami J.;
- Cardamone-Rayner, Mark;
- Hartman, James J.;
- Jacobson, Lewis A.
Publication type:
Article
DDX3X and specific initiation factors modulate FMR1 repeat‐associated non‐AUG‐initiated translation.
Published in:
EMBO Reports, 2019, v. 20, n. 9, p. N.PAG, doi. 10.15252/embr.201847498
By:
- Linsalata, Alexander E;
- He, Fang;
- Malik, Ahmed M;
- Glineburg, Mary Rebecca;
- Green, Katelyn M;
- Natla, Sam;
- Flores, Brittany N;
- Krans, Amy;
- Archbold, Hilary C;
- Fedak, Stephen J;
- Barmada, Sami J;
- Todd, Peter K
Publication type:
Article
Cytoplasmic Mislocalization of TDP-43 Is Toxic to Neurons and Enhanced by a Mutation Associated with Familial Amyotrophic Lateral Sclerosis.
Published in:
Journal of Neuroscience, 2010, v. 30, n. 2, p. 639, doi. 10.1523/JNEUROSCI.4988-09.2010
By:
- Barmada, Sami J.;
- Skibinski, Gaia;
- Korb, Erica;
- Rao, Elizabeth J.;
- Wu, Jane Y.;
- Finkbeiner, Steven
Publication type:
Article
N-Terminally Deleted Forms of the Prion Protein Activate Both Bax-Dependent and Bax-Independent Neurotoxic Pathways.
Published in:
Journal of Neuroscience, 2007, v. 27, n. 4, p. 852, doi. 10.1523/JNEUROSCI.4244-06.2007
By:
- Aimin Li;
- Barmada, Sami J.;
- Roth, Kevin A.;
- Harris, David A.
Publication type:
Article
Visualization of Prion Infection in Transgenic Mice Expressing Green Fluorescent Protein-Tagged Prion Protein.
Published in:
Journal of Neuroscience, 2005, v. 25, n. 24, p. 5824, doi. 10.1523/JNEUROSCI.1192-05.2005
By:
- Barmada, Sami J.;
- Harris, David A.
Publication type:
Article
Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice.
Published in:
EMBO Journal, 2007, v. 26, n. 11, p. 2777, doi. 10.1038/sj.emboj.7601726
By:
- Li, Aimin;
- Piccardo, Pedro;
- Barmada, Sami J.;
- Ghetti, Bernardino;
- Harris, David A.
Publication type:
Article
Opposed growth factor signals control protein degradation in muscles of Caenorhabditis elegans.
Published in:
EMBO Journal, 2007, v. 26, n. 4, p. 935, doi. 10.1038/sj.emboj.7601540
By:
- Szewczyk, Nathaniel J;
- Peterson, Brant K;
- Barmada, Sami J;
- Parkinson, Leah P;
- Jacobson, Lewis A
Publication type:
Article
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.
Published in:
2021
By:
- Haiyan Qiu;
- Sebum Lee;
- Yulei Shang;
- Wen-Yuan Wang;
- Kin Fai Au;
- Kamiya, Sherry;
- Barmada, Sami J.;
- Finkbeiner, Steven;
- Hansen Lui;
- Carlton, Caitlin E.;
- Tang, Amy A.;
- Oldham, Michael C.;
- Hejia Wang;
- Shorter, James;
- Filiano, Anthony J.;
- Roberson, Erik D.;
- Tourtellotte, Warren G.;
- Bin Chen;
- Li-Huei Tsai;
- Huang, Eric J.
Publication type:
journal article
Shortened TDP43 isoforms upregulated by neuronal hyperactivity drive TDP43 pathology in ALS.
Published in:
2020
By:
- Weskamp, Kaitlin;
- Tank, Elizabeth M.;
- Miguez, Roberto;
- McBride, Jonathon P.;
- Gómez, Nicolás B.;
- White, Matthew;
- Ziqiang Lin;
- Moreno Gonzalez, Carmen;
- Serio, Andrea;
- Sreedharan, Jemeen;
- Barmada, Sami J.;
- Lin, Ziqiang;
- Gonzalez, Carmen Moreno
Publication type:
journal article
miRNA analysis reveals novel dysregulated pathways in amyotrophic lateral sclerosis.
Published in:
Human Molecular Genetics, 2023, v. 32, n. 6, p. 934, doi. 10.1093/hmg/ddac250
By:
- Hur, Junguk;
- Paez-Colasante, Ximena;
- Figueroa-Romero, Claudia;
- Lo, Ting-wen;
- Barmada, Sami J;
- Paulsen, Michelle T;
- Ljungman, Mats;
- Alakwaa, Fadhl M;
- Savelieff, Masha G;
- Goutman, Stephen A;
- Feldman, Eva L
Publication type:
Article
Comment on "Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells".
Published in:
Science Translational Medicine, 2013, v. 5, n. 188, p. 1, doi. 10.1126/scitranslmed.3005065
By:
- Bilican, Bilada;
- Serio, Andrea;
- Barmada, Sami J.;
- Nishimura, Agnes Lumi;
- Sullivan, Gareth J.;
- Carrasco, Monica;
- Phatnani, Hemali P.;
- Puddifoot, Clare A.;
- Story, David;
- Fletcher, Judy;
- In-Hyun Park;
- Friedman, Brad A.;
- Daley, George Q.;
- Wyllie, David J. A.;
- Hardingham, Giles E.;
- Wilmut, Ian;
- Finkbeiner, Steven;
- Maniatis, Tom;
- Shaw, Christopher E.;
- Chandran, Siddharthan
Publication type:
Article
Distinct C9orf72-Associated Dipeptide Repeat Structures Correlate with Neuronal Toxicity.
Published in:
PLoS ONE, 2016, v. 11, n. 10, p. 1, doi. 10.1371/journal.pone.0165084
By:
- Flores, Brittany N.;
- Dulchavsky, Mark E.;
- Krans, Amy;
- Sawaya, Michael R.;
- Paulson, Henry L.;
- Todd, Peter K.;
- Barmada, Sami J.;
- Ivanova, Magdalena I.
Publication type:
Article
C-terminal frameshift variant of TDP-43 with pronounced aggregation-propensity causes rimmed vacuole myopathy but not ALS/FTD.
Published in:
Acta Neuropathologica, 2023, v. 145, n. 6, p. 793, doi. 10.1007/s00401-023-02565-1
By:
- Ervilha Pereira, Pedro;
- Schuermans, Nika;
- Meylemans, Antoon;
- LeBlanc, Pontus;
- Versluys, Lauren;
- Copley, Katie E.;
- Rubien, Jack D.;
- Altheimer, Christopher;
- Peetermans, Myra;
- Debackere, Elke;
- Vanakker, Olivier;
- Janssens, Sandra;
- Baets, Jonathan;
- Verhoeven, Kristof;
- Lammens, Martin;
- Symoens, Sofie;
- De Paepe, Boel;
- Barmada, Sami J.;
- Shorter, James;
- De Bleecker, Jan L.
Publication type:
Article
Stress granule formation helps to mitigate neurodegeneration.
Published in:
Nucleic Acids Research, 2024, v. 52, n. 16, p. 9745, doi. 10.1093/nar/gkae655
By:
- Glineburg, M Rebecca;
- Yildirim, Evrim;
- Gomez, Nicolas;
- Rodriguez, Genesis;
- Pak, Jaclyn;
- Li, Xingli;
- Altheim, Christopher;
- Waksmacki, Jacob;
- McInerney, Gerald M;
- Barmada, Sami J;
- Todd, Peter K
Publication type:
Article
Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeats.
Published in:
Nucleic Acids Research, 2024, v. 52, n. 10, p. 5928, doi. 10.1093/nar/gkae137
By:
- Tseng, Yi-Ju;
- Krans, Amy;
- Malik, Indranil;
- Deng, Xiexiong;
- Yildirim, Evrim;
- Ovunc, Sinem;
- Tank, Elizabeth M H;
- Jansen-West, Karen;
- Kaufhold, Ross;
- Gomez, Nicolas B;
- Sher, Roger;
- Petrucelli, Leonard;
- Barmada, Sami J;
- Todd, Peter K
Publication type:
Article
CGG repeats trigger translational frameshifts that generate aggregation-prone chimeric proteins.
Published in:
Nucleic Acids Research, 2022, v. 50, n. 15, p. 8674, doi. 10.1093/nar/gkac626
By:
- Wright, Shannon E;
- Rodriguez, Caitlin M;
- Monroe, Jeremy;
- Xing, Jiazheng;
- Krans, Amy;
- Flores, Brittany N;
- Barsur, Venkatesha;
- Ivanova, Magdalena I;
- Koutmou, Kristin S;
- Barmada, Sami J;
- Todd, Peter K
Publication type:
Article
RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response.
Published in:
Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-02200-0
By:
- Green, Katelyn M.;
- Glineburg, M. Rebecca;
- Kearse, Michael G.;
- Flores, Brittany N.;
- Linsalata, Alexander E.;
- Fedak, Stephen J.;
- Goldstrohm, Aaron C.;
- Barmada, Sami J.;
- Todd, Peter K.
Publication type:
Article
Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit.
Published in:
Neurology & Therapy, 2023, v. 12, n. 6, p. 1821, doi. 10.1007/s40120-023-00548-8
By:
- Sattler, Rita;
- Traynor, Bryan J.;
- Robertson, Janice;
- Van Den Bosch, Ludo;
- Barmada, Sami J.;
- Svendsen, Clive N.;
- Disney, Matthew D.;
- Gendron, Tania F.;
- Wong, Philip C.;
- Turner, Martin R.;
- Boxer, Adam;
- Babu, Suma;
- Benatar, Michael;
- Kurnellas, Michael;
- Rohrer, Jonathan D.;
- Donnelly, Christopher J.;
- Bustos, Lynette M.;
- Van Keuren-Jensen, Kendall;
- Dacks, Penny A.;
- Sabbagh, Marwan N.
Publication type:
Article
Cytoplasmic TDP43 Binds microRNAs: New Disease Targets in Amyotrophic Lateral Sclerosis.
Published in:
Frontiers in Cellular Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fncel.2020.00117
By:
- Paez-Colasante, Ximena;
- Figueroa-Romero, Claudia;
- Rumora, Amy E.;
- Hur, Junguk;
- Mendelson, Faye E.;
- Hayes, John M.;
- Backus, Carey;
- Taubman, Ghislaine F.;
- Heinicke, Laurie;
- Walter, Nils G.;
- Barmada, Sami J.;
- Sakowski, Stacey A.;
- Feldman, Eva L.
Publication type:
Article
Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.
Published in:
Nature Chemical Biology, 2014, v. 10, n. 8, p. 677, doi. 10.1038/nchembio.1563
By:
- Barmada, Sami J;
- Serio, Andrea;
- Arjun, Arpana;
- Bilican, Bilada;
- Daub, Aaron;
- Ando, D Michael;
- Tsvetkov, Andrey;
- Pleiss, Michael;
- Li, Xingli;
- Peisach, Daniel;
- Shaw, Christopher;
- Chandran, Siddharthan;
- Finkbeiner, Steven
Publication type:
Article

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