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- Title
Within-host evolutionary dynamics of seasonal and pandemic human influenza A viruses in young children.
- Authors
Han, Alvin X.; Garza, Zandra C. Felix; Welkers, Matthijs R. A.; Vigeveno, René M.; Nhu Duong Tran; Thi Quynh Mai Le; Thai Pham Quang; Dinh Thoang Dang; Thi Ngoc Anh Tran; Manh Tuan Ha; Thanh Hung Nguyen; Quoc Thinh Le; Thanh Hai Le; Thi Bich Ngoc Hoang; Chokephaibulkit, Kulkanya; Puthavathana, Pilaipan; Van Vinh Chau Nguyen; My Ngoc Nghiem; Van Kinh Nguyen; Tuyet Trinh Dao
- Abstract
The evolution of influenza viruses is fundamentally shaped by within-host processes. However, the within-host evolutionary dynamics of influenza viruses remain incompletely understood, in part because most studies have focused on infections in healthy adults based on single timepoint data. Here, we analyzed the within-host evolution of 82 longitudinally sampled individuals, mostly young children, infected with A/H1N1pdm09 or A/H3N2 viruses between 2007 and 2009. For A/H1N1pdm09 infections during the 2009 pandemic, nonsynonymous minority variants were more prevalent than synonymous ones. For A/H3N2 viruses in young children, early infection was dominated by purifying selection. As these infections progressed, nonsynonymous variants typically increased in frequency even when within-host virus titers decreased. Unlike the short-lived infections of adults where de novo within-host variants are rare, longer infections in young children allow for the maintenance of virus diversity via mutation-selection balance creating potentially important opportunities for within-host virus evolution.
- Subjects
INFLUENZA viruses; INFLUENZA A virus; PANDEMICS; INFLUENZA; SEASONS; H1N1 influenza; VIRUS diversity; ADULTS
- Publication
eLife, 2021, p1
- ISSN
2050-084X
- Publication type
Article
- DOI
10.7554/eLife.68917