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- Title
Mendelian randomization analysis provides causality of smoking on the expression of ACE2, a putative SARS- CoV-2 receptor.
- Authors
Hui Liu; Junyi Xin; Sheng Cai; Xia Jiang
- Abstract
Background: To understand a causal role of modifiable lifestyle factors in angiotensin-converting enzyme 2 (ACE2) expression (a putative severe acute respiratory syndrome coronavirus 2 [SARS- CoV-2] receptor) across 44 human tissues/organs, and in coronavirus disease 2019 (COVID-19) susceptibility and severity, we conducted a phenome-wide two-sample Mendelian randomization (MR) study. Methods: More than 500 genetic variants were used as instrumental variables to predict smoking and alcohol consumption. Inverse-variance weighted approach was adopted as the primary method to estimate a causal association, while MR-Egger regression, weighted median, and MR pleiotropy residual sum and outlier (MR-PRESSO) were performed to identify potential horizontal pleiotropy. Results: We found that genetically predicted smoking intensity significantly increased ACE2 expression in thyroid (b=1.468, p=1.810
- Subjects
COVID-19; ANGIOTENSIN converting enzyme; SARS-CoV-2; GENETIC variation; SMOKING
- Publication
eLife, 2021, p1
- ISSN
2050-084X
- Publication type
Article
- DOI
10.7554/eLife.64188