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- Title
胰腺癌组织中 L1 细胞黏附分子和转化生长因子 β1 的表达及意义.
- Authors
秦 雯; 杨建宇; 陈泰文; 郑海平; 朱小东
- Abstract
Objective To investigate the expression of Ll cell adhesion molecule ( L1CAM ) and transforming growth factor —131 ( TGFβ1 ) in pancreatic cancer tissue and their association with the prognosis of pancreatic cancer. Methods Histological specimens were collected from 125 patients with pancreatic cancer who underwent surgical resection in The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University Cancer Hospital, and Wuming Hospital of Guangxi Medical University from January 2015 to January 2018. 1m-munohistochemistry was used to measure the expression of L1CAM and TGFβ1 in all specimens, and the association of the expression of L1CAM and TGFβ1 with clinical indices, survival, and prognosis was analyzed. The t — test was used for comparison of continuous data be-tween two groups, and the chi — square test was used for comparison of categorical data between two groups; the Cox proportional — hazards regression model was used to investigate the influencing factors for the survival of patients with pancreatic cancer; the Kaplan — Meier survival analysis was used to evaluate the survival of patients with different expression levels of L1CAM and TGFβ1. Results The high protein ex-pression rate of Ll CAM in pancreatic cancer tissue was significantly higher than that in adjacent tissue (75.20% vs 20.00%, X² = 7 6. 352, P < 0.001 ). The high protein expression rate of TGFβ1 in pancreatic cancer tissue was significantly higher than that in adjacent tissue ( 81. 60% vs 23.20%, X² = 85.461, P < 0.001 ). The protein expression of Ll CAM was positively correlated with that of TG931 in pancre-atic cancer ( r =0.492, P <0.001). The protein expression of LI CAM and TGFβ1 were associated with tumor size, degree of tumor differ-entiation, TNM stage, lymph node metastasis, intravascular tumor thrombus, and perinea al invasion ( all P <0. 05 ). The patients with high protein expression of Ll CAM or TGFβ1 had a significantly lower overall survival rate than those with low expression ( = 54. 661 and 39.597, both P <0.001 ). Conclusion L1CAM and TGFβ1 proteins are highly expressed in pancreatic cancer tissue and may be associat-ed with poor prognosis by promoting lymphatic metastasis and hematogenous metastasis. Ll CAM and TGFβ1 proteins play an important role in the development, progression, and metastasis of pancreatic cancer.
- Publication
Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi, 2021, Vol 37, Issue 6, p1404
- ISSN
1001-5256
- Publication type
Article
- DOI
10.3969/j.issn.1001-5256.2021.06.035