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- Title
Mitotic arrest induced in human DU145 prostate cancer cells in response to KHC-4 treatment.
- Authors
Shen, Cheng‐Huang; Lin, Tien‐Huang; Hsieh, You‐Liang; Shen, Chia‐Yao; Kuo, Sheng‐Chu; Wu, Hsi‐Chin; Chien, Wen‐Shin; Hsieh, Dennis Jine‐Yuan; Wen, Su‐Ying; Ting, Wei‐Jen; Yao, Chun‐Hsu; Huang, Chih‐Yang
- Abstract
In this study, the antitumor activity of KHC-4 was analyzed using human prostate cancer (CaP) cells and the underlining anticancer mechanisms of KHC-4 were identified. KHC-4 inhibited cell proliferation and induced cytotoxicity in the castration-resistant CaP DU145 cell line. The most effective concentration of KHC-4 was 0.1 μM. Cell cycle analysis demonstrated that KHC-4 treatment caused G2/M arrest and a subsequent increase in the sub-G1 population. Furthermore, KHC-4 is up-regulated p21, p27, and p53 in a time- and concentration-dependent manner. The exposure of cells to KHC-4 induced Cdk1/cyclin B1 complex activity, which led to cell cycle arrest. Moreover, KHC-4 inhibited the activities of MMP-2 and MMP-9 to inhibit tumor cell metastasis. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1879-1887, 2016.
- Subjects
POTASSIUM; CELL lines; ANTINEOPLASTIC agents; CELL proliferation; CELL cycle regulation; CELL migration; THERAPEUTICS
- Publication
Environmental Toxicology, 2016, Vol 31, Issue 12, p1879
- ISSN
1520-4081
- Publication type
Article
- DOI
10.1002/tox.22189