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- Title
Treating Steroid Refractory Intestinal Acute Graft-vs.-Host Disease With Fecal Microbiota Transplantation: A Pilot Study.
- Authors
Qi, Xiaofei; Li, Xuewei; Zhao, Ye; Wu, Xiaojin; Chen, Feng; Ma, Xiao; Zhang, Faming; Wu, Depei
- Abstract
Patients with steroid refractory gastrointestinal (GI) tract graft- vs.-host disease (GvHD) face a poor prognosis and limited therapeutic options. To accurately assess the efficacy and safety of fecal microbiota transplantation (FMT) in treating steroid refractory GI tract GvHD, we conducted a pilot study involving eight patients. Having received FMTs, all patients' clinical symptoms relieved, bacteria enriched, and microbiota composition reconstructed. Compared to those who did not receive FMT, these eight patients achieved a higher progression-free survival. FMT can serve as a therapeutic option for GI tract aGVHD, but its effectiveness and safety need further evaluations. Clinical Trial Registration: NCT03148743.
- Subjects
GASTROINTESTINAL disease diagnosis; GASTROINTESTINAL disease treatment; FECAL microbiota transplantation; DIARRHEA; HEMATOPOIETIC stem cell transplantation
- Publication
Frontiers in Immunology, 2018, pN.PAG
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2018.02195