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- Title
Appetite during the recovery phase of critical illness: a cohort study.
- Authors
Merriweather, Judith L; Griffith, David M; Walsh, Timothy S
- Abstract
<bold>Background/objectives: </bold>Reduced appetite is a recognised physiological symptom in survivors of critical illness. While reduced appetite has been reported by patients after intensive care unit (ICU) discharge, quantification using visual analogue scales (VAS) has not been previously performed, and follow-up duration has been limited. We aimed to describe appetite scores in ICU survivors during the first 3 months after ICU discharge and explore association with systemic inflammation.<bold>Subjects/methods: </bold>Secondary analysis of data collected in a complex rehabilitation intervention trial (RECOVER). A subgroup of 193 patients provided specific consent for inclusion in the blood sampling sub-study during consent for the main study. We studied appetite using a VAS; serum C-reactive protein (CRP); interleukin-1β and interleukin-6 (IL-1β and IL-6); and hand-grip strength.<bold>Results: </bold>Median (interquartile range) score on 0-10 appetite VAS was 4.3 (2.0-6.5) 1 week after ICU discharge, improving to 7.1 (4.6-8.9) by 3 months (mean difference 1.7 (0.9-2.4), p < 0.01). Number of days spent in an acute hospital following an intensive care stay was associated with poorer appetite scores (p = 0.03). CRP concentration and appetite were significantly associated at 1 week after ICU discharge (p = 0.01), but not at 3 months after ICU discharge (p = 0.67).<bold>Conclusions: </bold>ICU survivors experience reduced appetite during the acute recovery phase of critical illness that could impact on nutritional recovery and this was associated with CRP concentration 1 week after ICU discharge.
- Subjects
CATASTROPHIC illness; APPETITE; C-reactive protein; COMPARATIVE studies; CRITICAL care medicine; GRIP strength; LENGTH of stay in hospitals; INTENSIVE care units; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; RESEARCH; RESEARCH funding; EVALUATION research; DISCHARGE planning; THERAPEUTICS
- Publication
European Journal of Clinical Nutrition, 2018, Vol 72, Issue 7, p986
- ISSN
0954-3007
- Publication type
journal article
- DOI
10.1038/s41430-018-0181-3