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Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.
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- Angewandte Chemie, 2017, v. 129, n. 42, p. 13191, doi. 10.1002/ange.201707324
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- Article
Structural characterization and functional properties of a novel lipomannan variant isolated from a Corynebacterium glutamicum pimB' mutant.
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- Antonie van Leeuwenhoek, 2008, v. 94, n. 2, p. 277, doi. 10.1007/s10482-008-9243-1
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- Article
Mannan core branching of lipo(arabino)mannan is required for mycobacterial virulence in the context of innate immunity.
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- Cellular Microbiology, 2013, v. 15, n. 12, p. 2093, doi. 10.1111/cmi.12175
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- Article
Non-glycosidic compounds can stimulate both human and mouse iNKT cells.
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- European Journal of Immunology, 2016, v. 46, n. 5, p. 1224, doi. 10.1002/eji.201546114
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- Article
Mycobacterial receptor, Clec4d (CLECSF8, MCL), is coregulated with Mincle and upregulated on mouse myeloid cells following microbial challenge.
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- European Journal of Immunology, 2016, v. 46, n. 2, p. 381, doi. 10.1002/eji.201545858
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- Article
Gal-3 regulates the capacity of dendritic cells to promote NKT-cell-induced liver injury.
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- European Journal of Immunology, 2015, v. 45, n. 2, p. 531, doi. 10.1002/eji.201444849
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- Article
Invariant natural killer T cells are not affected by lysosomal storage in patients with Niemann- Pick disease type C.
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- European Journal of Immunology, 2012, v. 42, n. 7, p. 1886, doi. 10.1002/eji.201141821
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- Article
Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.
- Published in:
- Angewandte Chemie International Edition, 2017, v. 56, n. 42, p. 13011, doi. 10.1002/anie.201707324
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- Article
Role of lipid trimming and CD1 groove size in cellular antigen presentation.
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- EMBO Journal, 2006, v. 25, n. 13, p. 2989, doi. 10.1038/sj.emboj.7601185
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- Article
Generation of Liposomes to Study the Effect of Mycobacterium Tuberculosis Lipids on HIV-1 cis - and trans -Infections.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 4, p. 1945, doi. 10.3390/ijms22041945
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- Article
A mycolic acid-specific CD1-restricted T cell population contributes to acute and memory immune responses in human tuberculosis infection.
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- 2011
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- journal article
Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice.
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- 2011
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- journal article
Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity.
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- 2011
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- journal article
Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity.
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- 2011
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- journal article
Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function.
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- 2010
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- journal article
Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans.
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- 2008
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- journal article
Sustained activation and tumor targeting of NKT cells using a CD1d-anti-HER2-scFv fusion protein induce antitumor effects in mice.
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- 2008
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- Publication type:
- journal article
The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system.
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- Biochemical Journal, 2020, v. 477, n. 10, p. 1983, doi. 10.1042/BCJ20200194
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- Article
Development of a novel secondary phenotypic screen to identify hits within the mycobacterial protein synthesis pipeline.
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- FASEB Bioadvances, 2020, v. 2, n. 10, p. 600, doi. 10.1096/fba.2020-00022
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- Article
A novel mutation alters the stability of PapA2 resulting in the complete abrogation of sulfolipids in clinical mycobacterial strains.
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- FASEB Bioadvances, 2019, v. 1, n. 5, p. 306, doi. 10.1096/fba.2018-00039
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- Article
Development of a whole‐cell high‐throughput phenotypic screen to identify inhibitors of mycobacterial amino acid biosynthesis.
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- FASEB Bioadvances, 2019, v. 1, n. 4, p. 246, doi. 10.1096/fba.2018-00048
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- Article
A humanized mouse model for in vivo evaluation of invariant Natural Killer T cell responses.
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- Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.1011209
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- Article
The bovine CD1D gene has an unusual gene structure and is expressed but cannot present α-galactosylceramide with a C26 fatty acid.
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- International Immunology, 2013, v. 25, n. 2, p. 91, doi. 10.1093/intimm/dxs092
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- Article
BCR targeting of biotin-α-galactosylceramide leads to enhanced presentation on CD1d and requires transport of BCR to CD1d-containing endocytic compartments.
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- International Immunology, 2005, v. 17, n. 7, p. 899, doi. 10.1093/intimm/dxh269
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- Article
DprE1 Inhibitors: Enduring Aspirations for Future Antituberculosis Drug Discovery.
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- ChemMedChem, 2023, v. 18, n. 16, p. 1, doi. 10.1002/cmdc.202300099
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- Article
Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen.
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- Scientific Reports, 2016, p. 38986, doi. 10.1038/srep38986
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- Article
Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase.
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- Scientific Reports, 2016, p. 23191, doi. 10.1038/srep23191
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- Article
Promotion or Suppression of Murine Intestinal Polyp Development by iNKT Cell Directed Immunotherapy.
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- Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.00352
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- Article
Lipoarabinomannan biosynthesis in Corynebacterineae: the interplay of two α(1→2)-mannopyranosyltransferases MptC and MptD in mannan branching.
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- Molecular Microbiology, 2011, v. 80, n. 5, p. 1241, doi. 10.1111/j.1365-2958.2011.07640.x
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- Article
3-Ketosteroid 9α-hydroxylase is an essential factor in the pathogenesis of Mycobacterium tuberculosis.
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- Molecular Microbiology, 2010, v. 75, n. 1, p. 107, doi. 10.1111/j.1365-2958.2009.06957.x
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- Article
Biosynthesis of mycobacterial arabinogalactan: identification of a novel α(1→3) arabinofuranosyltransferase.
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- Molecular Microbiology, 2008, v. 69, n. 5, p. 1191, doi. 10.1111/j.1365-2958.2008.06354.x
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- Article
Identification of a novel α(1→6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant.
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- Molecular Microbiology, 2008, v. 68, n. 6, p. 1595, doi. 10.1111/j.1365-2958.2008.06265.x
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- Article
Identification of an α(1→6) mannopyranosyltransferase (MptA), involved in Corynebacterium glutamicum lipomanann biosynthesis, and identification of its orthologue in Mycobacterium tuberculosis.
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- Molecular Microbiology, 2007, v. 65, n. 6, p. 1503, doi. 10.1111/j.1365-2958.2007.05884.x
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- Article
A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis.
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- Molecular Microbiology, 2007, v. 65, n. 3, p. 684, doi. 10.1111/j.1365-2958.2007.05827.x
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- Article
The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development.
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- Molecular Microbiology, 2007, v. 64, n. 6, p. 1442, doi. 10.1111/j.1365-2958.2007.05761.x
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- Article
Identification of the lipooligosaccharide biosynthetic gene cluster from Mycobacterium marinum.
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- Molecular Microbiology, 2007, v. 63, n. 5, p. 1345, doi. 10.1111/j.1365-2958.2007.05603.x
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- Article
Characterization of the putative operon containing arylamine N-acetyltransferase ( nat) in Mycobacterium bovis BCG.
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- Molecular Microbiology, 2006, v. 59, n. 1, p. 181, doi. 10.1111/j.1365-2958.2005.04945.x
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- Article
Identification and structural characterization of an unusual mycobacterial monomeromycolyl-diacylglycerol.
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- Molecular Microbiology, 2005, v. 57, n. 4, p. 1113, doi. 10.1111/j.1365-2958.2005.04717.x
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- Article
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
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- Molecular Microbiology, 2004, v. 53, n. 2, p. 391, doi. 10.1111/j.1365-2958.2004.04183.x
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- Article
EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator.
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- Molecular Microbiology, 2004, v. 51, n. 1, p. 175, doi. 10.1046/j.1365-2958.2003.03809.x
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- Article
Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis.
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- Molecular Microbiology, 2002, v. 46, n. 2, p. 453, doi. 10.1046/j.1365-2958.2002.03162.x
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- Publication type:
- Article
DprE2 is a molecular target of the anti-tubercular nitroimidazole compounds pretomanid and delamanid.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39300-z
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- Article
Osteological, Biomolecular and Geochemical Examination of an Early Anglo-Saxon Case of Lepromatous Leprosy.
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- PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0124282
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- Article
MKAN27435 Is Required for the Biosynthesis of Higher Subclasses of Lipooligosaccharides in Mycobacterium kansasii.
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- PLoS ONE, 2015, v. 10, n. 4, p. 1, doi. 10.1371/journal.pone.0122804
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- Article
Mycobacterial Dihydrofolate Reductase Inhibitors Identified Using Chemogenomic Methods and In Vitro Validation.
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- PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0121492
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- Article
Biochemical and Structural Characterization of Mycobacterial Aspartyl-tRNA Synthetase AspS, a Promising TB Drug Target.
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- PLoS ONE, 2014, v. 9, n. 11, p. 1, doi. 10.1371/journal.pone.0113568
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- Article
Improving Mycobacterium bovis Bacillus Calmette-Guèrin as a Vaccine Delivery Vector for Viral Antigens by Incorporation of Glycolipid Activators of NKT Cells.
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- PLoS ONE, 2014, v. 9, n. 9, p. 1, doi. 10.1371/journal.pone.0108383
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- Article
Non-Replicating <i>Mycobacterium tuberculosis</i> Elicits a Reduced Infectivity Profile with Corresponding Modifications to the Cell Wall and Extracellular Matrix.
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- PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0087329
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- Article
Gram-Positive Bacterial Lipoglycans Based on a Glycosylated Diacylglycerol Lipid Anchor Are Microbe-Associated Molecular Patterns Recognized by TLR2.
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- PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0081593
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- Article
Osteological and Biomolecular Evidence of a 7000-Year-Old Case of Hypertrophic Pulmonary Osteopathy Secondary to Tuberculosis from Neolithic Hungary.
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- PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0078252
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- Article