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- Title
Evolución del patrón de sensibilidad de Escherichia coli en infecciones del tracto urinario diagnosticadas en la comunidad durante el periodo 2003-2007. Estudio multicéntrico en Castilla la Mancha.
- Authors
Tena, Daniel; González-Praetorius, Alejandro; González, José Carlos; Heredero, Eva; Illescas, Soledad; de Baranda, Caridad Sáinz; Seseña, Germán
- Abstract
Objective: To know the evolution of susceptibility patterns of Escherichia coli in patients with communitydiagnosed urinary tract infections (UTIs) during last years in Castilla la Mancha (Spain). Methods: Descriptive and retrospective study performed between january 2003 and december 2007. We studied data about frequency and susceptibility of 33.651 E. coli isolates from urine cultures that were remited from primary care centres depending of 6 hospitals in Castilla la Mancha (Spain). Results: Susceptibility rates of E. coli for most antibiotics decreased significantly during the 5-year period, especially for amoxicillin-clavulanic acid, cefuroxime and quinolones. Average rates of susceptibility for amoxicillin- clavulanic acid, ciprofloxacin, cefuroxime, fosfomycin and nitrofurantoin were: 86,7, 75,4, 87,3, 97,6 and 96,2%, respectively. We observed a significantly increase of E. coli isolates producing extended-spectrum betalactamases (ESBLs), from 1,9% in 2003 to 4,9% in 2007 (χ2 TL = 143,6, p<0,001). Conclusions: We observed a significantly reduction of E. coli susceptibility for most antibiotics and an increase of E. coli isolates producing ESBLs. Fosfomycin and nitrofurantoin are the best choices for empiric treatment. Prospective studies should be performed in the future to confirm the results of our study.
- Subjects
SPAIN; MICROBIAL sensitivity tests; ESCHERICHIA coli; URINARY tract infections; FOSFOMYCIN; DISEASE susceptibility; RETROSPECTIVE studies
- Publication
Revista Española de Quimioterapia, 2010, Vol 23, Issue 1, p36
- ISSN
0214-3429
- Publication type
Article