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- Title
Alignments of endocrine, anthropometric, and metabolic parameters in type 2 diabetes after intervention with an Okinawa-based Nordic diet.
- Authors
Ohlsson, Bodil; Darwiche, Gassan; Roth, Bodil; Höglund, Peter
- Abstract
Background: An Okinawa-based Nordic diet with moderately low carbohydrate content and high fat and protein content has been shown to improve anthropometry and metabolism in type 2 diabetes. Objective: The objectives of this study were to measure plasma or serum levels of hormones regulating energy metabolism and metabolic control, that is, cholecystokinin (CCK), Cortisol, C-peptide, ghrelin, glucagon, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), insulin, leptin, plasminogen activator inhibitor-1 (PAI-1), polypeptide YY (PYY), resistin, and visfatin after this diet intervention, and to determine partial correlations between hormonal levels and anthropometric and metabolic responses. Design: A total of 30 patients (17 women) with type 2 diabetes, mean age 57.5 ± 8.2 years, and body mass index (BMI) 29.9 ± 4.1 kg/m2 were served the diet for 12 weeks. Fasting hormones were measured by Luminex and enzyme--linked immunosorbent assay (ELISA) before study start and after 12 and 28 weeks, along with anthropometric and metabolic parameters. Result: The levels of CCK (P = 0.005), cortisol (P = 0.015), C-peptide (P = 0.022), glucagon (P = 0.003), GLP-1 (P = 0.013), GIP (P < 0.001), insulin (P = 0.004), leptin (P < 0.001), and PYY (P < 0.001) were lowered after dietary intervention. These reduced levels only remained for PYY at week 28 (P = 0.002), when also ghrelin (P = 0.012) and visfatin (P = 0.021) levels were reduced. Changes of glucose values correlated with changed levels of C-peptide and PYY (P < 0.001), insulin (P = 0.002), and PAI-1 (P = 0.009); changes of triglyceride values with changed levels of C-peptide, insulin, and PYY (P < 0.001) and PAI-1 (P = 0.005); changes of insulin resistance with changes of leptin levels (P = 0.003); and changes of BMI values with changed levels of C-peptide, insulin, and leptin (P < 0.001). Conclusions: Okinawa-based Nordic diet in type 2 diabetes has significant impact on the endocrine profile, which correlates with anthropometric and metabolic improvements.
- Subjects
SCANDINAVIA; SWEDEN; ENDOCRINE system physiology; ANTHROPOMETRY; BLOOD coagulation factors; C-peptide; CHOLECYSTOKININ; STATISTICAL correlation; DIET; ENERGY metabolism; ENZYME-linked immunosorbent assay; GASTROINTESTINAL hormones; GLUCAGON; HYDROCORTISONE; INSULIN; INSULIN resistance; TYPE 2 diabetes; PEPTIDE hormones; TRANSFERASES; GLUCAGON-like peptide 1; LEPTIN; GHRELIN; BODY mass index; TREATMENT effectiveness; ADIPOKINES; RESISTIN; BLOOD
- Publication
Food & Nutrition Research, 2018, Vol 62, p1
- ISSN
1654-6628
- Publication type
Article
- DOI
10.29219/fnr.v62.1328