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- Title
DEVELOPMENT AND EVALUATION OF FLAVOXATE HCI DOUBLE CORE COMPRESSED TABLET FORMULATIONS BY SWELLABLE GRANULATION TECHNIQUE.
- Authors
RASHID, AHMAD JUNAID; BASHIR, SAJID; IJAZ, QAZI AMIR; ABBAS, NASIR; BUKHARI, NADEEM IRFAN; ISHTIAQ, SAIQA; RASOOL, SHAHID; RAZA, ATIF; ANWER, UBAID ULLAH
- Abstract
The objective of the proposed research was to develop double core differential release tablets of Flavoxate HCl, a smooth-muscle relaxant through the swellable technique. Inner core granules were prepared by a wet granulation method using HPMC K15 and Kollidon as sustained-release polymers. Outer core immediate release granules were also prepared by a wet granulation method using standard tableting excipients. Both types of granules were evaluated for pharmaceutical, structural, and thermal parameters. The double core tablet was prepared using a pre-compressed inner tablet. In vitro release studies were performed in 0.1 N HCl (pH 1.2) and phosphate buffer (pH 7.4) as dissolution media. Stability studies were also performed on the selected formulations. Pharmaceutical evaluation results of inner core granules prepared by HPMC K15 and Kollidon and tablets showed acceptable values for all the physical parameters. FTIR studies showed that the principal peaks of the drug remained intact, indicating no chemical interaction occurred between drug and a polymer. DSC results showed no noteworthy change in the thermal behavior of the drug while in granular formulation. Inner core tablets were successfully compressed with acceptable results of friability, hardness, thickness, diameter, and content uniformity parameters. Double core tablets were prepared by employing immediate release granules as the outer core with intact tablets as the inner core, and all the uniformity parameters of the prepared tablets were found to be within the acceptable limits. In vitro release studies in both media showed a characteristic sustained drug release pattern for up to 24 hours. Results of stability studies indicated that all the formulations remained stable.
- Subjects
DRUG tablets; POLYMERS; GRANULATION; THERMAL analysis; DRUGS
- Publication
Acta Poloniae Pharmaceutica, 2022, Vol 79, Issue 5, p667
- ISSN
0001-6837
- Publication type
Article
- DOI
10.32383/appdr/142315