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- Title
In vitro nifedipine release from poly(lactic acid)/chitosan nanoparticles loaded with nifedipine.
- Authors
Chinh, Nguyen Thuy; Trang, Nguyen Thi Thu; Giang, Nguyen Vu; Thanh, Dinh Thi Mai; Hang, To Thi Xuan; Tung, Nguyen Quang; Truyen, Chu Quang; Quan, Pham Minh; Long, Pham Quoc; Hoang, Thai
- Abstract
ABSTRACT In this study, nanoparticles based on poly(lactic acid) (PLA), chitosan (CS), and nifedipine (NIF) were prepared by an emulsion method with poly(ethylene oxide) (PEO) as an emulsifier. We investigated the most suitable conditions for preparing the poly(lactic acid)/chitosan/nifedipine nanoparticles (PCNs) by changing the distilled water volume, PEO content, and PLA/CS ratio. NIFs with different contents were loaded into poly(lactic acid)/chitosan nanoparticles (PCs) to study in vitro drug-delivery systems. The PCNs were characterized with a Zetasizer particle size analyzer, field emission scanning electron microscopy, Fourier transform infrared (FTIR) spectroscopy, and X-ray diffraction (XRD) methods. From the obtained results of the particle size parameters of the PCNs, the most suitable conditions for the preparation of the PCNs were found. The FTIR spectroscopy and XRD results show that NIF was loaded into the PCs. The PCNs had major basic particle sizes in the range 20-40 nm. NIF release from the PCNs was studied as a function of the pH of the immersed solution, the immersion time, and the NIF content. The kinetics of drug release were investigated and are reported to determine the type of release mechanism. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43330.
- Subjects
NIFEDIPINE; NANOPARTICLES; STABILIZING agents; X-ray diffraction; FOURIER transform infrared spectroscopy
- Publication
Journal of Applied Polymer Science, 2016, Vol 133, Issue 16, pn/a
- ISSN
0021-8995
- Publication type
Article
- DOI
10.1002/app.43330