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- Title
A signature of differential gene expression in bronchoalveolar lavage fluid predicts mortality in influenza-associated pulmonary aspergillosis.
- Authors
Feys, Simon; Heylen, Jannes; Carvalho, Agostinho; Van Weyenbergh, Johan; Wauters, Joost; on behalf of the Variomic Study Group; Gonçalves, Samuel M.; Cunha, Cristina; Debaveye, Yves; Hermans, Greet; Humblet-Baron, Stephanie; Jacobs, Cato; Lambrechts, Diether; Mombaerts, Peter; Lagrou, Katrien; Meersseman, Philippe; Menezes, Soraya Maria; Peetermans, Marijke; Rocha-Pereira, Joana; Seldeslachts, Laura
- Abstract
Given this finding, we assessed whether the protein VEGF is associated with IAPA mortality as well using a dataset of BAL VEGF levels obtained from 40 patients, of whom 38 were included in the gene expression dataset [[2]]. We conclude that decreased lower respiratory tract expression of genes related to anti I Aspergillus i immunity and increased VEGF levels and VEGF-related signaling are associated with increased mortality in IAPA patients.
- Subjects
GENE expression; PULMONARY eosinophilia; GENE ontology; BRONCHOALVEOLAR lavage; PULMONARY aspergillosis
- Publication
Intensive Care Medicine, 2023, Vol 49, Issue 2, p254
- ISSN
0342-4642
- Publication type
Article
- DOI
10.1007/s00134-022-06958-w