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- Title
Rhodium-Catalyzed Cyclization of Diynes with Nitrones: A Formal [2+2+5] Approach to Bridged Eight-Membered Heterocycles.
- Authors
Wang, Chunxiang; Wang, Dongping; Yan, Hao; Wang, Haolong; Pan, Bin; Xin, Xiaoyi; Li, Xincheng; Wu, Fan; Wan, Boshun
- Abstract
N-aryl-substituted nitrones were employed as five-atom coupling partners in the rhodium-catalyzed cyclization with diynes. In this reaction, the nitrone moiety served as a directing group for the catalytic CH activation of the N-aryl ring. This formal [2+2+5] approach allows rapid access to bridged eight-membered heterocycles with broad substrate scope. The results of this study may provide new insight into the chemistry of nitrones and find applications in the synthesis of other heterocycles.
- Subjects
RHODIUM catalysts; NITRONES; HETEROCYCLIC compounds; COUPLING agents (Chemistry); FUNCTIONAL groups
- Publication
Angewandte Chemie International Edition, 2014, Vol 53, Issue 44, p11940
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201407394