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CSF or serum neurofilament light added to α-Synuclein panel discriminates Parkinson's from controls.
Published in:
2020
By:
- Oosterveld, Linda P.;
- Verberk, Inge M.W.;
- Majbour, Nour K.;
- El‐Agnaf, Omar M.;
- Weinstein, Henry C.;
- Berendse, Henk W.;
- Teunissen, Charlotte E.;
- Berg, Wilma D.J.;
- El-Agnaf, Omar M;
- van de Berg, Wilma D J
Publication type:
journal article
α-Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies.
Published in:
2018
By:
- Steenoven, Inger;
- Majbour, Nour K.;
- Vaikath, Nishant N.;
- Berendse, Henk W.;
- Flier, Wiesje M.;
- Berg, Wilma D.J.;
- Teunissen, Charlotte E.;
- Lemstra, Afina W.;
- El‐Agnaf, Omar M.A.;
- van Steenoven, Inger;
- van der Flier, Wiesje M;
- van de Berg, Wilma D J;
- El-Agnaf, Omar M A
Publication type:
journal article
A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations.
Published in:
2017
By:
- Mollenhauer, Brit;
- Batrla, Richard;
- El‐Agnaf, Omar;
- Galasko, Douglas R.;
- Lashuel, Hilal A.;
- Merchant, Kalpana M.;
- Shaw, Lesley M.;
- Selkoe, Dennis J.;
- Umek, Robert;
- Vanderstichele, Hugo;
- Zetterberg, Henrik;
- Zhang, Jing;
- Caspell‐Garcia, Chelsea;
- Coffey, Chris;
- Hutten, Samantha J.;
- Frasier, Mark;
- Taylor, Peggy;
- El-Agnaf, Omar;
- Caspell-Garcia, Chelsea;
- Investigating Synuclein Consortium of the Michael J. Fox Foundation for Parkinson's Research
Publication type:
journal article
Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts.
Published in:
BMC Complementary Medicine & Therapies, 2020, v. 20, n. 1, p. 1, doi. 10.1186/s12906-020-2849-1
By:
- Ardah, Mustafa T.;
- Ghanem, Simona S.;
- Abdulla, Sara A.;
- Lv, Guohua;
- Emara, Mohamed M.;
- Paleologou, Katerina E.;
- Vaikath, Nishant N.;
- Lu, Jia-Hong;
- Li, Min;
- Vekrellis, Konstantinos;
- Eliezer, David;
- El-Agnaf, Omar M. A.
Publication type:
Article
Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease.
Published in:
NPJ Parkinson's Disease, 2021, v. 7, n. 1, p. 1, doi. 10.1038/s41531-021-00203-9
By:
- Oliveira, Luis M. A.;
- Gasser, Thomas;
- Edwards, Robert;
- Zweckstetter, Markus;
- Melki, Ronald;
- Stefanis, Leonidas;
- Lashuel, Hilal A.;
- Sulzer, David;
- Vekrellis, Kostas;
- Halliday, Glenda M.;
- Tomlinson, Julianna J.;
- Schlossmacher, Michael;
- Jensen, Poul Henning;
- Schulze-Hentrich, Julia;
- Riess, Olaf;
- Hirst, Warren D.;
- El-Agnaf, Omar;
- Mollenhauer, Brit;
- Lansbury, Peter;
- Outeiro, Tiago F.
Publication type:
Article
Early-onset parkinsonism in a pedigree with phosphoglycerate kinase deficiency and a heterozygous carrier: do PGK-1 mutations contribute to vulnerability to parkinsonism?
Published in:
NPJ Parkinson's Disease, 2017, v. 3, n. 1, p. N.PAG, doi. 10.1038/s41531-017-0014-4
By:
- Sakaue, Satoshi;
- Kasai, Takashi;
- Mizuta, Ikuko;
- Suematsu, Masaya;
- Osone, Shinya;
- Azuma, Yumiko;
- Imamura, Toshihiko;
- Tokuda, Takahiko;
- Kanno, Hitoshi;
- El-Agnaf, Omar M. A.;
- Morimoto, Masafumi;
- Nakagawa, Masanori;
- Hosoi, Hajime;
- Mizuno, Toshiki
Publication type:
Article
Complex I reductions in the nucleus basalis of Meynert in Lewy body dementia: the role of Lewy bodies.
Published in:
Acta Neuropathologica Communications, 2020, v. 8, n. 1, p. 1, doi. 10.1186/s40478-020-00985-8
By:
- Hatton, Christopher;
- Reeve, Amy;
- Lax, Nichola Zoe;
- Blain, Alasdair;
- Ng, Yi Shiau;
- El-Agnaf, Omar;
- Attems, Johannes;
- Taylor, John-Paul;
- Turnbull, Doug;
- Erskine, Daniel
Publication type:
Article
Paving the Way toward Personalized Medicine: Current Advances and Challenges in Multi-OMICS Approach in Autism Spectrum Disorder for Biomarkers Discovery and Patient Stratification.
Published in:
Journal of Personalized Medicine, 2021, v. 11, n. 1, p. 41, doi. 10.3390/jpm11010041
By:
- Mesleh, Areej G.;
- Abdulla, Sara A.;
- El-Agnaf, Omar
Publication type:
Article
Elevated expression of CYP1A1 and γ-SYNUCLEIN in human ectopic (ovarian) endometriosis compared with eutopic endometrium.
Published in:
Molecular Human Reproduction, 2008, v. 14, n. 11, p. 655, doi. 10.1093/molehr/gan056
By:
- Singh, Maneesh N.;
- Stringfellow, Helen F.;
- Taylor, Siân E.;
- Ashton, Kate M.;
- Ahmad, Mushfika;
- Abdo, Khalil R.;
- El-Agnaf, Omar M.A.;
- Martin-Hirsch, Pierre L.;
- Martin, Francis L.
Publication type:
Article
Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson's disease.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-37464-2
By:
- Nim, Satra;
- O'Hara, Darren M.;
- Corbi-Verge, Carles;
- Perez-Riba, Albert;
- Fujisawa, Kazuko;
- Kapadia, Minesh;
- Chau, Hien;
- Albanese, Federica;
- Pawar, Grishma;
- De Snoo, Mitchell L.;
- Ngana, Sophie G.;
- Kim, Jisun;
- El-Agnaf, Omar M. A.;
- Rennella, Enrico;
- Kay, Lewis E.;
- Kalia, Suneil K.;
- Kalia, Lorraine V.;
- Kim, Philip M.
Publication type:
Article
Prion-like α-synuclein pathology in the brain of infants with Krabbe disease.
Published in:
2022
By:
- Hatton, Christopher;
- Ghanem, Simona S.;
- Koss, David J.;
- Abdi, Ilham Y.;
- Gibbons, Elizabeth;
- Guerreiro, Rita;
- Bras, Jose;
- Consortium, International DLB Genetics;
- Walker, Lauren;
- Gelpi, Ellen;
- Heywood, Wendy;
- Outeiro, Tiago F.;
- Attems, Johannes;
- McFarland, Robert;
- Forsyth, Rob;
- El-Agnaf, Omar M.;
- Erskine, Daniel;
- International DLB Genetics Consortium
Publication type:
journal article
Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates.
Published in:
2020
By:
- Arotcarena, Marie-Laure;
- Dovero, Sandra;
- Prigent, Alice;
- Bourdenx, Mathieu;
- Camus, Sandrine;
- Porras, Gregory;
- Thiolat, Marie-Laure;
- Tasselli, Maddalena;
- Aubert, Philippe;
- Kruse, Niels;
- Mollenhauer, Brit;
- Damas, Ines Trigo;
- Estrada, Cristina;
- Garcia-Carrillo, Nuria;
- Vaikath, Nishant N;
- El-Agnaf, Omar M A;
- Herrero, Maria Trinidad;
- Vila, Miquel;
- Obeso, Jose A;
- Derkinderen, Pascal
Publication type:
journal article
α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson's disease model.
Published in:
Brain: A Journal of Neurology, 2020, v. 143, n. 1, p. 249, doi. 10.1093/brain/awz380
By:
- Taguchi, Tomoyuki;
- Ikuno, Masashi;
- Hondo, Mari;
- Parajuli, Laxmi Kumar;
- Taguchi, Katsutoshi;
- Ueda, Jun;
- Sawamura, Masanori;
- Okuda, Shinya;
- Nakanishi, Etsuro;
- Hara, Junko;
- Uemura, Norihito;
- Hatanaka, Yusuke;
- Ayaki, Takashi;
- Matsuzawa, Shuichi;
- Tanaka, Masaki;
- El-Agnaf, Omar M A;
- Koike, Masato;
- Yanagisawa, Masashi;
- Uemura, Maiko T;
- Yamakado, Hodaka
Publication type:
Article
Alpha-synuclein targets GluN2A NMDA receptor subunit causing striatal synaptic dysfunction and visuospatial memory alteration.
Published in:
2019
By:
- Durante, Valentina;
- Iure, Antonio de;
- Loffredo, Vittorio;
- Vaikath, Nishant;
- Risi, Maria De;
- Paciotti, Silvia;
- Quiroga-Varela, Ana;
- Chiasserini, Davide;
- Mellone, Manuela;
- Mazzocchetti, Petra;
- Calabrese, Valeria;
- Campanelli, Federica;
- Mechelli, Alessandro;
- Filippo, Massimiliano Di;
- Ghiglieri, Veronica;
- Picconi, Barbara;
- El-Agnaf, Omar M.;
- Leonibus, Elvira De;
- Gardoni, Fabrizio;
- Tozzi, Alessandro
Publication type:
journal article
α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson's disease model.
Published in:
2019
By:
- Taguchi, Tomoyuki;
- Ikuno, Masashi;
- Hondo, Mari;
- Parajuli, Laxmi Kumar;
- Taguchi, Katsutoshi;
- Ueda, Jun;
- Sawamura, Masanori;
- Okuda, Shinya;
- Nakanishi, Etsuro;
- Hara, Junko;
- Uemura, Norihito;
- Hatanaka, Yusuke;
- Ayaki, Takashi;
- Matsuzawa, Shuichi;
- Tanaka, Masaki;
- El-Agnaf, Omar M A;
- Koike, Masato;
- Yanagisawa, Masashi;
- Uemura, Maiko T;
- Yamakado, Hodaka
Publication type:
journal article
Brain propagation of transduced α-synuclein involves non-fibrillar protein species and is enhanced in α-synuclein null mice.
Published in:
2016
By:
- Helwig, Michael;
- Klinkenberg, Michael;
- Rusconi, Raffaella;
- Musgrove, Ruth E.;
- Majbour, Nour K.;
- El-Agnaf, Omar M. A.;
- Ulusoy, Ayse;
- Di Monte, Donato A.
Publication type:
journal article
Correlated levels of cerebrospinal fluid pathogenic proteins in drug‐naïve Parkinson's disease: Biomarkers (non‐neuroimaging) / Differential diagnosis.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.036258
By:
- Ono, Kenjiro;
- Murakami, Hidetomo;
- El‐Agnaf, Omar M.A.;
- Tokuda, Takahiko;
- Ohmichi, Takuma;
- Miki, Ayako;
- Ohashi, Hideaki;
- Owan, Yoshiyuki;
- Saito, Yu;
- Yano, Satoshi;
- Tsukie, Tamao;
- Ikeuchi, Takeshi
Publication type:
Article
O2‐09‐04: HARMONIZATION OF IMMUNOCHEMICAL METHODS FOR MEASUREMENT OF α‐SYNUCLEIN IN HUMAN CEREBROSPINAL FLUID: A ROUND ROBIN STUDY APPROACH.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P642, doi. 10.1016/j.jalz.2018.06.2691
By:
- Hutten, Samantha J.;
- Mollenhauer, Brit;
- Bowman, F Dubois;
- Drake, Daniel;
- Duong, Jimmy;
- Blennow, Kaj;
- Corradini, Veronika;
- El-Agnaf, Omar M.A.;
- Shaw, Leslie M.;
- Masucci, Jennifer;
- Taylor, Peggy;
- Umek, Robert M.;
- Dunty, Jill;
- Smith, Chris L.;
- Stoops, Erik;
- Vanderstichele, Hugo Marcel;
- Schmid, Adrien W.;
- Moniatte, Marc;
- Zhang, Jing;
- Kruse, Niels
Publication type:
Article
Blood Proteomics Analysis Reveals Potential Biomarkers and Convergent Dysregulated Pathways in Autism Spectrum Disorder: A Pilot Study.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 8, p. 7443, doi. 10.3390/ijms24087443
By:
- Mesleh, Areej;
- Ehtewish, Hanan;
- de la Fuente, Alberto;
- Al-shamari, Hawra;
- Ghazal, Iman;
- Al-Faraj, Fatema;
- Al-Shaban, Fouad;
- Abdesselem, Houari B.;
- Emara, Mohamed;
- Alajez, Nehad M.;
- Arredouani, Abdelilah;
- Decock, Julie;
- Albagha, Omar;
- Stanton, Lawrence W.;
- Abdulla, Sara A.;
- El-Agnaf, Omar M. A.
Publication type:
Article
Circulating MicroRNA Profiling Identifies Distinct MicroRNA Signatures in Acute Ischemic Stroke and Transient Ischemic Attack Patients.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 1, p. 108, doi. 10.3390/ijms24010108
By:
- Toor, Salman M.;
- Aldous, Eman K.;
- Parray, Aijaz;
- Akhtar, Naveed;
- Al-Sarraj, Yasser;
- Abdelalim, Essam M.;
- Arredouani, Abdelilah;
- El-Agnaf, Omar;
- Thornalley, Paul J.;
- Pananchikkal, Sajitha V.;
- Pir, Ghulam Jeelani;
- Ayadathil, Raheem;
- Shuaib, Ashfaq;
- Alajez, Nehad M.;
- Albagha, Omar M. E.
Publication type:
Article
Structural and Biophysical Characterization of Stable Alpha-Synuclein Oligomers.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 23, p. 14630, doi. 10.3390/ijms232314630
By:
- Vaikath, Nishant;
- Sudhakaran, Indulekha;
- Abdi, Ilham;
- Gupta, Vijay;
- Majbour, Nour;
- Ghanem, Simona;
- Abdesselem, Houari;
- Vekrellis, Kostas;
- El-Agnaf, Omar
Publication type:
Article
Diagnostic, Prognostic, and Mechanistic Biomarkers of Diabetes Mellitus-Associated Cognitive Decline.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 11, p. 6144, doi. 10.3390/ijms23116144
By:
- Ehtewish, Hanan;
- Arredouani, Abdelilah;
- El-Agnaf, Omar
Publication type:
Article
Identification of Novel Circulating miRNAs in Patients with Acute Ischemic Stroke.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 6, p. 3387, doi. 10.3390/ijms23063387
By:
- Aldous, Eman K.;
- Toor, Salman M.;
- Parray, Aijaz;
- Al-Sarraj, Yasser;
- Diboun, Ilhame;
- Abdelalim, Essam M.;
- Arredouani, Abdelilah;
- El-Agnaf, Omar;
- Thornalley, Paul J.;
- Akhtar, Naveed;
- Pananchikkal, Sajitha V.;
- Shuaib, Ashfaq;
- Alajez, Nehad M.;
- Albagha, Omar M. E.
Publication type:
Article
CSF Biomarkers Reflecting Protein Pathology and Axonal Degeneration Are Associated with Memory, Attentional, and Executive Functioning in Early-Stage Parkinson′s Disease.
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 22, p. 8519, doi. 10.3390/ijms21228519
By:
- Oosterveld, Linda P.;
- Kuiper, Tessa I.;
- Majbour, Nour K.;
- Verberk, Inge M. W.;
- van Dijk, Karin D.;
- Twisk, Jos W. R.;
- El-Agnaf, Omar M.;
- Teunissen, Charlotte E.;
- Weinstein, Henry C.;
- Klein, Martin;
- Berendse, Henk W.;
- van de Berg, Wilma D. J.
Publication type:
Article
Tissue-Specific Delivery of CRISPR Therapeutics: Strategies and Mechanisms of Non-Viral Vectors.
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 19, p. 7353, doi. 10.3390/ijms21197353
By:
- Shalaby, Karim;
- Aouida, Mustapha;
- El-Agnaf, Omar
Publication type:
Article
Elevated levels of cerebrospinal fluid α-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers.
Published in:
Frontiers in Aging Neuroscience, 2014, v. 6, p. 1, doi. 10.3389/fnagi.2014.00248
By:
- Aasly, Jan O.;
- Johansen, Krisztina K.;
- Brønstad, Gunnar;
- Warø, Bjørg J.;
- Majbour, Nour K.;
- Varghese, Shiji;
- Alzahmi, Fatimah;
- Paleologou, Katerina E.;
- Amer, Dena A. M.;
- Al-Hayani, Abdulmonem;
- El-Agnaf, Omar M. A.
Publication type:
Article
Structure activity relationship of phenolic acid inhibitors of α-synuclein fibril formation and toxicity.
Published in:
Frontiers in Aging Neuroscience, 2014, v. 6, p. 1, doi. 10.3389/fnagi.2014.00197
By:
- Ardah, Mustafa T.;
- Paleologou, Katerina E.;
- Lv, Guohua;
- Abul Khair, Salema B.;
- Kazim, Abdulla S.;
- Minhas, Saeed T.;
- Al-Tel, Taleb H.;
- Al-Hayani, Abdulmonem A.;
- Haque, Mohammed E.;
- Eliezer, David;
- El-Agnaf, Omar M. A.
Publication type:
Article
ALPHA-SYNUCLEIN SPECIES AS POTENTIAL CSF BIOMARKERS FOR DEMENTIA WITH LEWY BODIES.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P338, doi. 10.1016/j.jalz.2017.06.063
By:
- van Steenoven, Inger;
- Majbour, Nour K.;
- Vaikath, Nishant N.;
- Berendse, Henk W.;
- van der Flier, Wiesje M.;
- Van de Berg, Wilma D.J.;
- Teunissen, Charlotte E.;
- El-Agnaf, Omar M.A.;
- Lemstra, Afina W.
Publication type:
Article
PERFORMANCE EVALUATION OF NEW ABSORBANCE-BASED ELISAS FOR MEASURING DIFFERENT ALPHA-SYNUCLEIN (A-SYN) SPECIES IN CSF AND PLASMA.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P677, doi. 10.1016/j.jalz.2016.06.1330
By:
- Stoops, Erik;
- Majbour, Nour;
- Mauroo, Kimberley;
- Demeyer, Leentje;
- Lashuel, Hilal;
- Trojanowski, John Q.;
- M-Y Lee, Virginia;
- El Agnaf, Omar;
- Vanderstichele, Hugo Marcel
Publication type:
Article
STANDARDIZATION OF PRE-ANALYTICAL PROCEDURES FOR COLLECTION AND STORAGE OF CSF FOR THE MEASUREMENT OF NEUROGRANIN TRUNC P75 AND A-SYNUCLEIN.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P1155, doi. 10.1016/j.jalz.2016.07.059
By:
- Stoops, Erik;
- Janelidze, Shorena;
- Demeyer, Leentje;
- Coart, Els;
- Mauroo, Kimberley;
- Majbour, Nour;
- El Agnaf, Omar;
- Hansson, Oskar;
- Vanderstichele, Hugo
Publication type:
Article
Quantification of CSF and blood alpha-synuclein as a diagnostic marker for synucleinopathies
Published in:
2009
By:
- Mollenhauer, Brit;
- Birgit, Otte;
- Ng, Juliana;
- El-Agnaf, Omar;
- Scherzer, Clemens;
- Trenkwalde, Claudia
Publication type:
Abstract
Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer's disease.
Published in:
Scientific Reports, 2017, p. 40263, doi. 10.1038/srep40263
By:
- Majbour, Nour K.;
- Chiasserini, Davide;
- Vaikath, Nishant N.;
- Eusebi, Paolo;
- Tokuda, Takahiko;
- van de Berg, Wilma;
- Parnetti, Lucilla;
- Calabresi, Paolo;
- El-Agnaf, Omar M. A.
Publication type:
Article
Decrease in Plasma Levels of α-Synuclein Is Evident in Patients with Parkinson’s Disease after Elimination of Heterophilic Antibody Interference.
Published in:
PLoS ONE, 2015, v. 10, n. 4, p. 1, doi. 10.1371/journal.pone.0123162
By:
- Ishii, Ryotaro;
- Tokuda, Takahiko;
- Tatebe, Harutsugu;
- Ohmichi, Takuma;
- Kasai, Takashi;
- Nakagawa, Masanori;
- Mizuno, Toshiki;
- El-Agnaf, Omar M. A.
Publication type:
Article
α-Synuclein Levels in Blood Plasma from LRRK2 Mutation Carriers.
Published in:
PLoS ONE, 2012, v. 7, n. 12, p. 1, doi. 10.1371/journal.pone.0052312
By:
- Gorostidi, Ana;
- Bergareche, Alberto;
- Ruiz-Martínez, Javier;
- Martí-Massó, José F.;
- Cruz, María;
- Varghese, Shiji;
- Qureshi, Mohamed M.;
- Alzahmi, Fatimah;
- Al-Hayani, Abdulmonem;
- de Munáin, Adolfo López;
- El-Agnaf, Omar M. A.
Publication type:
Article
Cerebrospinal Fluid α -Synuclein Species in Cognitive and Movements Disorders.
Published in:
Brain Sciences (2076-3425), 2021, v. 11, n. 1, p. 119, doi. 10.3390/brainsci11010119
By:
- Constantinides, Vasilios C.;
- Majbour, Nour K.;
- Paraskevas, George P.;
- Abdi, Ilham;
- Safieh-Garabedian, Bared;
- Stefanis, Leonidas;
- El-Agnaf, Omar M.;
- Kapaki, Elisabeth
Publication type:
Article
RT-QuIC Using C-Terminally Truncated α-Synuclein Forms Detects Differences in Seeding Propensity of Different Brain Regions from Synucleinopathies.
Published in:
Biomolecules (2218-273X), 2021, v. 11, n. 6, p. 820, doi. 10.3390/biom11060820
By:
- Poggiolini, Ilaria;
- Erskine, Daniel;
- Vaikath, Nishant N.;
- Ponraj, Janarthanan;
- Mansour, Said;
- Morris, Christopher M.;
- El-Agnaf, Omar M. A.
Publication type:
Article
Expression, purification and characterization of α-synuclein fibrillar specific scFv from inclusion bodies.
Published in:
PLoS ONE, 2020, v. 15, n. 11, p. 1, doi. 10.1371/journal.pone.0241773
By:
- Gupta, Vijay;
- Sudhakaran, Indulekha P.;
- Islam, Zeyaul;
- Vaikath, Nishant N.;
- Hmila, Issam;
- Lukacsovich, Tamas;
- Kolatkar, Prasanna R.;
- El-Agnaf, Omar M. A.
Publication type:
Article
Certain Inhibitors of Synthetic Amyloid β-Peptide (Aβ) Fibrillogenesis Block Oligomerization of Natural Aβ and Thereby Rescue Long-Term Potentiation.
Published in:
Journal of Neuroscience, 2005, v. 25, n. 10, p. 2455, doi. 10.1523/JNEUROSCI.4391-04.2005
By:
- Walsh, Dominic M.;
- Townsend, Matthew;
- Podlisny, Marcia B.;
- Shankar, Ganesh M.;
- Fadeeva, Julia V.;
- El Agnaf, Omar;
- Hartley, Dean M.;
- Selkoe, Dennis J.
Publication type:
Article
Novel engineered nanobodies specific for N‐terminal region of alpha‐synuclein recognize Lewy‐body pathology and inhibit in‐vitro seeded aggregation and toxicity.
Published in:
FEBS Journal, 2022, v. 289, n. 15, p. 4657, doi. 10.1111/febs.16376
By:
- Hmila, Issam;
- Vaikath, Nishant N.;
- Majbour, Nour K.;
- Erskine, Daniel;
- Sudhakaran, Indulekha P.;
- Gupta, Vijay;
- Ghanem, Simona S.;
- Islam, Zeyaul;
- Emara, Mohamed M.;
- Abdesselem, Houari B.;
- Kolatkar, Prasanna R.;
- Achappa, Devaya K.;
- Vinardell, Tatiana;
- El‐Agnaf, Omar M. A.
Publication type:
Article
Baicalein Inhibits Formation of α-Synuclein Oligomers within Living Cells and Prevents Aβ Peptide Fibrillation and Oligomerisation.
Published in:
ChemBioChem, 2011, v. 12, n. 4, p. 615, doi. 10.1002/cbic.201000604
By:
- Lu, Jia-Hong;
- Ardah, Mustafa Taleb;
- Durairajan, Siva Sundara Kumar;
- Liu, Liang-Feng;
- Xie, Li-Xia;
- Fong, Wang-Fun David;
- Hasan, Mohamed Y.;
- Huang, Jian-Dong;
- El-Agnaf, Omar M. A.;
- Li, Min
Publication type:
Article
Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-65035-8
By:
- Gupta, Vijay;
- Salim, Safa;
- Hmila, Issam;
- Vaikath, Nishant N.;
- Sudhakaran, Indulekha P.;
- Ghanem, Simona S.;
- Majbour, Nour K.;
- Abdulla, Sara A.;
- Emara, Mohamed M.;
- Abdesselem, Houari B.;
- Lukacsovich, Tamas;
- Erskine, Daniel;
- El-Agnaf, Omar M. A.
Publication type:
Article
Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies.
Published in:
2009
By:
- Paleologou KE;
- Kragh CL;
- Mann DM;
- Salem SA;
- Al-Shami R;
- Allsop D;
- Hassan AH;
- Jensen PH;
- El-Agnaf OM;
- Paleologou, Katerina E;
- Kragh, Christine L;
- Mann, David M A;
- Salem, Sultan A;
- Al-Shami, Rania;
- Allsop, David;
- Hassan, Ahmed H;
- Jensen, Poul H;
- El-Agnaf, Omar M A
Publication type:
journal article
Detection of elevated levels of soluble {alpha}-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies.
Published in:
Brain: A Journal of Neurology, 2009, v. 132, n. 4, p. 1093
By:
- Katerina E. Paleologou;
- Christine L. Kragh;
- David M. A. Mann;
- Sultan A. Salem;
- Rania Al-Shami;
- David Allsop;
- Ahmed H. Hassan;
- Poul H. Jensen;
- Omar M. A. El-Agnaf
Publication type:
Article
Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson's disease with dementia and dementia with Lewy bodies compared to Alzheimer's disease.
Published in:
Alzheimer's Research & Therapy, 2014, v. 6, n. 3, p. 1, doi. 10.1186/alzrt255
By:
- Hansson, Oskar;
- Hall, Sara;
- Öhrfelt, Annika;
- Zetterberg, Henrik;
- Blennow, Kaj;
- Minthon, Lennart;
- Nägga, Katarina;
- Londos, Elisabet;
- Varghese, Shiji;
- Majbour, Nour K.;
- Al-Hayani, Abdulmonem;
- El-Agnaf, Omar M. A.
Publication type:
Article
Investigating the presence of doubly phosphorylated α‐synuclein at tyrosine 125 and serine 129 in idiopathic Lewy body diseases.
Published in:
Brain Pathology, 2020, v. 30, n. 4, p. 831, doi. 10.1111/bpa.12845
By:
- Fayyad, Muneera;
- Erskine, Daniel;
- Majbour, Nour K.;
- Vaikath, Nishant N.;
- Ghanem, Simona S.;
- Sudhakaran, Indulekha P.;
- Abdesselem, Houari;
- Lamprokostopoulou, Agaristi;
- Vekrellis, Kostas;
- Morris, Christopher M.;
- Attems, Johannes;
- El‐Agnaf, Omar M. A.
Publication type:
Article
γ-Synuclein and the progression of cancer.
Published in:
FASEB Journal, 2007, v. 21, n. 13, p. 3419, doi. 10.1096/fj.07-8379rev
By:
- Ahmad, Mushfika;
- Attoub, Samir;
- Singh, Maneesh N.;
- Martin, Francis L.;
- El-Agnaf, Omar M. A.
Publication type:
Article
Detection of oligomeric forms of α-synuclein protein in human plasma as a potential biomarker for Parkinson's disease.
Published in:
FASEB Journal, 2006, v. 20, n. 3, p. 419, doi. 10.1096/fj.03-1449com
By:
- El-Agnaf, Omar M. A.;
- Salem, Sultan A.;
- Paleologou, Katerina E.;
- Curran, Martin D.;
- Gibson, Mark J.;
- Court, Jennifer A.;
- Schlossmacher, Michael G.;
- Allsop, David
Publication type:
Article
A strategy for designing inhibitors of α-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders.
Published in:
FASEB Journal, 2004, v. 18, n. 11, p. 1315, doi. 10.1096/fj.03-1346fje
By:
- El-Agnaf, Omar M. A.;
- Paleologou, Katerina E.;
- Greer, Brett;
- Abogrein, Abdulmawala M.;
- King, Jenny E.;
- Salem, Sultan A.;
- Fullwood, Nigel J.;
- Benson, Fiona E.;
- Hewitt, Rebecca;
- Ford, Kirstie J.;
- Martin, Francis L.;
- Harriott, Patrick;
- Cookson, Mark R.;
- Allsop, David
Publication type:
Article
α-Synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma.
Published in:
FASEB Journal, 2003, v. 17, n. 13, p. 1945, doi. 10.1096/fj.03-0098fje
By:
- El-Agnaf, Omar M. A.;
- Salem, Sultan A.;
- Paleologou, Katerina E.;
- Cooper, Leanne J.;
- Fullwood, Nigel J.;
- Gibson, Mark J.;
- Curran, Martin D.;
- Court, Jennifer A.;
- Mann, David M. A.;
- Ikeda, Shu-Ichi;
- Cookson, Mark R.;
- Hardy, John;
- Allsop, David
Publication type:
Article
Parkinson's disease biomarkers based on α‐synuclein.
Published in:
Journal of Neurochemistry, 2019, v. 150, n. 5, p. 626, doi. 10.1111/jnc.14809
By:
- Fayyad, Muneera;
- Salim, Safa;
- Majbour, Nour;
- Erskine, Daniel;
- Stoops, Erik;
- Mollenhauer, Brit;
- El‐Agnaf, Omar M. A.
Publication type:
Article

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