We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Safflower seed extract in the treatment of human periodontal osseous defects.
- Authors
Bansal, Monika; Dixit, Jaya; Tyagi, Dhan Prakash
- Abstract
Brief Background Periodontal regeneration involves many cellular events. The objective of this study was to explore the possibilities of use of safflower seed extract in the treatment of human periodontal osseous defects. Materials and Methods Twenty one, two-wall infrabony defect sites from fifteen patients were randomly and equally divided into three treatment groups. These groups comprised Safflower seed extract (SSE)/collagen (SSE/Col), Saline/ Col and Surgical control group. The clinical parameters, i.e., probing pocket depth reduction (PPDR), clinical attachment level gain (CALG) and defect fill (DF) were measured at baseline along with 6 months surgical reentry. Data were analyzed using paired student 't' test for comparison between pre and post surgical recording for each treatment group and unpaired student 't' test for comparison between treatment groups. The level of significance for analysis was set at p=0.05. Results The results suggest that SSE/Col group showed significant difference from surgical control group and greater improvement without being statistically significant from Saline /Col group in each clinical parameter. Mean defect fill of 2.86mm (62.85%) and 2.43mm (54.85%) was obtained in SSE/Col group and Saline/Col group respectively which is 8% greater Summary and Conclusions The study indicated that safflower seed extract may be a novel approach in periodontal regeneration. It may be used to enhance the regenerative potential of various graft materials or membrane after combining with them. However, further histological and clinical studies are needed to evaluate its regenerative potential.
- Subjects
PERIODONTAL disease treatment; SAFFLOWER; MEDICINAL plants; PROGENITOR cells; PLANT extracts; BONE regeneration
- Publication
JIDA: Journal of Indian Dental Association, 2014, Vol 8, Issue 2, p8
- ISSN
0019-4611
- Publication type
Article