We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Extracellular histones indicate the prognosis in patients undergoing extracorporeal membrane oxygenation therapy.
- Authors
Wen, Zongmei; Jin, Yang; Jiang, Xuemei; Sun, Meng; Arman, Nazzarena; Wen, Tao; Lv, Xin
- Abstract
Introduction: Extracellular histones have been recently identified as damage-associated molecular-pattern (DAMP) molecules involved with the pathogenesis of various inflammatory diseases. This study intended to investigate whether extracellular histones can indicate the prognosis in critically ill patients supported by extracorporeal membrane oxygenation (ECMO) therapy. Methods: A total of 56 patients undergoing ECMO were analysed retrospectively. Median concentrations of extracellular histones in patients before ECMO were assessed and used to divide the patients into two groups (Group 1 <48 µg/ml and Group 2 ⩾48 µg/ml). Mortality rate, Sequential Organ Failure Assessment (SOFA) scores and systemic inflammation were compared between the groups. Results: There were relatively higher concentrations of extracellular histones in Group 2 patients (57.78 µg/ml [48.4, 71.3]) than in Group 1 patients (36.76 µg/ml [28.5, 39.3], p<0.0001). The hospital mortality rate was 55.4% for the entire study subjects, with significantly worsened mortality in Group 2 in contrast to Group 1 (58.8% vs. 50%, p=0.031). Moreover, Group 2 patients had significantly higher SOFA scores and more pronounced systemic inflammation than Group 1 patients prior to ECMO initialization. Conclusions: Extracellular histones are known contributors to cell damage and organ injury. Our study showed that extracellular histones have a predictive value in the assessment of outcome of patients undergoing ECMO therapy and may be helpful for risk stratification in clinical settings.
- Subjects
CHINA; ADULT respiratory distress syndrome treatment; RESPIRATORY insufficiency treatment; SEPTIC shock treatment; INFLAMMATION; BLOOD collection; CRITICALLY ill; CYTOKINES; ENZYME-linked immunosorbent assay; EXTRACELLULAR space; EXTRACORPOREAL membrane oxygenation; HISTONES; PATIENTS; RESEARCH funding; RISK assessment; STATISTICS; T-test (Statistics); DATA analysis; RETROSPECTIVE studies; DATA analysis software; DESCRIPTIVE statistics; HOSPITAL mortality; MANN Whitney U Test; BLOOD; PROGNOSIS
- Publication
Perfusion, 2019, Vol 34, Issue 3, p211
- ISSN
0267-6591
- Publication type
Article
- DOI
10.1177/0267659118809557