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- Title
The changing HIV-1 genetic characteristics and transmitted drug resistance among recently infected population in Yunnan, China.
- Authors
Chen, M.; Jia, M. H.; Ma, Y. L.; Luo, H. B.; Chen, H. C.; Yang, C. J.; Dai, J.; Yang, L.; Dong, L. J.; Lu, R.; Song, L. J.; Han, Y.; Lu, J. Y.; Cheung, A. K. L.; Chen, Z. W.; Lu, L.
- Abstract
Multiple human immunodeficiency virus (HIV)-1 genotypes in China were first discovered in Yunnan Province before disseminating throughout the country. As the HIV-1 epidemic continues to expand in Yunnan, genetic characteristics and transmitted drug resistance (TDR) should be further investigated among the recently infected population. Among 2828 HIV-positive samples newly reported in the first quarter of 2014, 347 were identified as recent infections with BED-captured enzyme immunoassay (CEIA). Of them, 291 were successfully genotyped and identified as circulating recombinant form (CRF)08_BC (47.4%), unique recombinant forms (URFs) (18.2%), CRF01_AE (15.8%), CRF07_BC (14.4%), subtype C (2.7%), CRF55_01B (0.7%), subtype B (0.3%) and CRF64_BC (0.3%). CRF08_BC and CRF01_AE were the predominant genotypes among heterosexual and homosexual infections, respectively. CRF08_BC, URFs, CRF01_AE and CRF07_BC expanded with higher prevalence in central and eastern Yunnan. The recent common ancestor of CRF01_AE, CRF07_BC and CRF08_BC dated back to 1983.1, 1992.1 and 1989.5, respectively. The effective population sizes (EPS) for CRF01_AE and CRF07_BC increased exponentially during 1991–1999 and 1994–1999, respectively. The EPS for CRF08_BC underwent two exponential growth phases in 1994–1998 and 2001–2002. Lastly, TDR-associated mutations were identified in 1.8% of individuals. These findings not only enhance our understanding of HIV-1 evolution in Yunnan but also have implications for vaccine design and patient management strategies.
- Subjects
YUNNAN Sheng (China); HIV infection genetics; HIV infections; THERAPEUTICS; GENOTYPES; DRUG resistance; DRUG design
- Publication
Epidemiology & Infection, 2018, Vol 146, Issue 6, p775
- ISSN
0950-2688
- Publication type
Article
- DOI
10.1017/S0950268818000389