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- Title
A hospital-based matched case-control study to identify risk factors for clinical infection with OXA-48-producing Klebsiella pneumoniae in rectal carriers.
- Authors
MADUEÑO, A.; GARCIA, J. GONZALEZ; AGUIRRE-JAIME, A.; LECUONA, M.; Madueño, A; Gonzalez Garcia, J
- Abstract
Asymptomatic colonisation of the gastrointestinal tract by carbapenemase-producing Enterobacteriaceae is an important reservoir for transmission, which may precede infection. This retrospective observational case-control study was designed to identify risk factors for developing clinical infection with OXA-48-producing Klebsiella pneumoniae in rectal carriers during hospitalisation. Case patients (n = 76) had carbapenemase-producing K. pneumoniae (CPKP) infection and positive rectal culture for CPKP. Control patients (n = 174) were those with rectal colonisation with CPKP but without CPKP infection. Multivariate analysis identified the presence of a central venous catheter (OR 4·38; 95% CI 2·27-8·42; P = 0·008), the number of transfers between hospital units (OR 1·27; 95% CI (1·06-1·52); P < 0·001) and time at risk (OR 1·02 95% CI 1·01-1·03; P = 0·01) as independent risk factors for CPKP infection in rectal carriers. Awareness of these risk factors may help to identify patients at higher risk of developing CPKP infection.
- Subjects
SPAIN; HOSPITAL care; HYDROLASES; KLEBSIELLA; RECTUM; RETROSPECTIVE studies; CASE-control method; KLEBSIELLA infections; PHYSIOLOGY
- Publication
Epidemiology & Infection, 2017, Vol 145, Issue 12, p2626
- ISSN
0950-2688
- Publication type
journal article
- DOI
10.1017/S095026881700142X