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- Title
Iodide-induced thyrotoxicosis in a thyroidectomized patient with metastatic thyroid carcinoma.
- Authors
Yoshinari, Mototaka; Tokuyama, Takashi; Okamura, Ken; Sato, Aori; Kusuda, Kenji; Fujishima, Masatoshi; Yoshinari, M; Tokuyama, T; Okamura, K; Sato, K; Kusuda, K; Fujishima, M
- Abstract
An unusual case of iodide-induced thyrotoxicosis is documented in this article. The patient was a 64-year-old euthyroid man with acromegaly. He also had multiple follicular and papillary thyroid carcinomas with a metastatic lesion in the lumbar vertebrae. After a total thyroidectomy, he became slightly hypothyroid, and the lumbar lesion began to incorporate 131I by scintigraphy. When an iodine-containing contrast medium happened to be injected, a transient increase of serum thyroid hormone level was observed. After complete thyroid ablation with 83 mCi of 131I, the oral administration of 100 mg of potassium iodide for 7 days induced a prominent increase of serum thyroid hormone level. These findings indicated that the metastatic thyroid carcinoma could produce excess thyroid hormone insofar as a sufficient amount of iodide was given. Although this is the first report of such a case, iodide-induced thyrotoxicosis may not be rare in patients with thyroid carcinomas because the Wolff-Chaikoff effect is thought to be lost, and the organic iodinating activity and lysosomal protease activity are well-preserved.
- Publication
Cancer (0008543X), 1988, Vol 61, Issue 8, p1674
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19880415)61:8<1674::AID-CNCR2820610827>3.0.CO;2-E