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- Title
Clinical effects of total-body hyperthermia combined with anticancer chemotherapy for far-advanced gastrointestinal cancer.
- Authors
Koga, Shigemasa; Maeta, Michio; Shimizu, Norio; Osaki, Yukio; Hamazoe, Ryuichi; Oda, Masayuki; Karino, Takuo; Yamane, Toshiaki; Koga, S; Maeta, M; Shimizu, N; Osaki, Y; Hamazoe, R; Oda, M; Karino, T; Yamane, T
- Abstract
The authors treated 17 patients with far-advanced gastrointestinal cancer with extracorporeally induced total-body hyperthermia (TBHT) combined with anticancer chemotherapy. Although all patients' tumors were clinically resistant to prior chemotherapy with 1-(2-tetrahydrofurlyl)-5-fluorouracil or 5-fluorouracil and mitomycin C, three patients had an objective response to TBHT plus the same anticancer agents with or without cyclophosphamide. That is, a partial response was obtained in 2 of 12 patients with recurrent gastric cancer and in 1 of 5 patients with recurrent large bowel cancer. However, their survival time was not markedly prolonged. As a characteristic complication of TBHT, the authors noted reversible weakness of the muscles of the lower extremities. Two patients died due to hepatorenal syndrome; preoperatively these patients had manifested hepatic or renal dysfunction. Therefore, in patients with hepatic or renal dysfunction, the application of TBHT must be considered carefully.
- Publication
Cancer (0008543X), 1985, Vol 55, Issue 8, p1641
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19850415)55:8<1641::AID-CNCR2820550805>3.0.CO;2-V