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- Title
Long-term survival in childhood acute lymphocytic leukemia in Italy.
- Authors
Mandelli, Franco; Amadori, Sergio; Ceci, Adriana; Guazzelli, Carlo; Madon, Enrico; Marchi, Antonietta; Masera, Giuseppe; Paolucci, Guido; Zanesco, Luigi; Mandelli, F; Amadori, S; Ceci, A; Guazzelli, C; Madon, E; Marchi, A; Masera, G; Paolucci, G; Zanesco, L
- Abstract
Among 727 children with acute lymphocytic leukemia (ALL) observed at eight pediatric clinics in Italy in the years 1967-1974, 200 (27.5%) survived for more than five years after diagnosis. The proportion of long-term survivors rose significantly during the years 1970-1974 when aggressive therapeutic programs with curative intent were uniformly adopted in Italy (19.8% vs. 29.4%; P less than 0.05). Clinical and laboratory data at diagnosis of the 200 long-term survivors were analyzed and compared with that of the 527 nonsurvivors. We found that, besides a leukocyte count greater than 50,000 cells/mm3, other factors such as early central nervous system CNS leukemia and the presence of mediastinal mass were predictive of a poorer prognosis for long-term survival. Life-table analysis revealed that the chance of long-term survival was significantly higher in those children who have survived for five years without relapse (82.9% vs. 24.1%; P less than 0.01). Although late initial relapse is always possible, if a child with ALL remains in continuous complete remission for at least nine years, it is likely that the patient is cured.
- Publication
Cancer (0008543X), 1981, Vol 48, Issue 11, p2364
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19811201)48:11<2364::AID-CNCR2820481104>3.0.CO;2-Y