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- Title
Intracavitary bleomycin in the management of malignant effusions.
- Authors
Paladine, William; Cunningham, Thomas J.; Sponzo, Robert; Donavan, Mark; Olson, Kenneth; Horton, John; Paladine, W; Cunningham, T J; Sponzo, R; Donavan, M; Olson, K; Horton, J
- Abstract
Instilled bleomycin and thoracostomy were utilized in 38 patients with malignant pleural effusions; the therapy produced a complete or partial response rate of 63%. Toxicity was minimal. In patients with intraperitoneal effusions, bleomycin instillation after drainage produced a complete or partial response in 36%. One patient had severe hypotension and fever. Patients with ovarian and breast carcinoma responded best, among them, effusions were controlled in greater that 70%. Because of its low systemic toxicity, absence of marrow toxicity, and virtual absence of discomfort, we think that the local instillation of bleomycin is indicated in the management of malignant effusions.
- Publication
Cancer (0008543X), 1976, Vol 38, Issue 5, p1903
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(197611)38:5<1903::AID-CNCR2820380506>3.0.CO;2-A