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- Title
Increased numbers of total nucleated and CD34+ cells in blood group O cord blood: an analysis of neonatal innate factors in the Korean population.
- Authors
Lee, Hye Ryun; Park, Jeong Su; Shin, Sue; Roh, Eun Youn; Yoon, Jong Hyun; Han, Kyou Sup; Kim, Byung Jae; Storms, Robert W.; Chao, Nelson J.
- Abstract
BACKGROUND: We analyzed neonatal factors that could affect hematopoietic variables of cord blood (CB) donated from Korean neonates. STUDY DESIGN AND METHODS: The numbers of total nucleated cells (TNCs), CD34+ cells, and CD34+ cells/TNCs of CB in neonates were compared according to sex, gestational age, birth weight, birth weight centile for gestational age, and ABO blood group. RESULTS: With 11,098 CB units analyzed, blood group O CB showed an increased number of TNCs, CD34+ cells, and CD34+ cells/TNCs compared with other blood groups. Although TNC counts were lower in males, no difference in the number of CD34+ cells was demonstrated because the number of CD34+ cells/TNCs was higher in males. An increase in the gestational age resulted in an increase in the number of TNCs and decreases in the number of CD34+ cells and CD34+ cells/TNCs. The numbers of TNCs, CD34+ cells, and CD34+ cells/TNCs increased according to increased birth weight centile as well as birth weight. CONCLUSION: CB with blood group O has unique hematologic variables in this large-scale analysis of Korean neonates, although the impact on the storage policies of CB banks or the clinical outcome of transplantation remains to be determined.
- Subjects
BLOOD cells; IMMUNOHEMATOLOGY; ABO blood group system; CORD blood; KOREANS; NEWBORN infant immunology; HEALTH
- Publication
Transfusion, 2012, Vol 52, Issue 1, p76
- ISSN
0041-1132
- Publication type
Article
- DOI
10.1111/j.1537-2995.2011.03262.x