We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Association between post-treatment circulating biomarkers of inflammation and survival among stage II-III colorectal cancer patients.
- Authors
Hua, Xinwei; Kratz, Mario; Malen, Rachel C.; Dai, James Y.; Lindström, Sara; Zheng, Yingye; Newcomb, Polly A.
- Abstract
<bold>Background: </bold>Biomarker studies on colorectal cancer (CRC) prognosis are limited to pre-diagnostic or pre-operative measures. Post-treatment biomarkers are not well understood for their associations with CRC survival.<bold>Methods: </bold>We included 306 eligible incident stage II-III CRC cases from the population-based Seattle Colon Cancer Family Registry. Concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), adiponectin, and leptin were measured using post-treatment plasma samples. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and CRC-specific mortality were calculated using Cox proportional hazard models.<bold>Results: </bold>Elevated levels of CRP, IL-6, MCP-1, and adiponectin were significantly associated with a higher risk of all-cause mortality within 10 years post blood draw with HRs (95% CI) of 1.32 (1.10-2.59), 2.72 (2.07-3.56), 1.97 (1.18-3.28) and 1.71 (1.14-2.58), respectively. IL-6 and adiponectin had a dose-response effect (Ptrend < 0.0001). For CRC-specific mortality, we observed positive associations for CRP (HR = 1.75, 95% CI: 1.2-2.56), IL-6 (HR = 5.02, 95% CI: 2.92-8.59), MCP-1 (HR = 3.78, 95% CI: 1.41-10.08), and adiponectin (HR = 3.16, 95% CI: 1.27-7.86), and inverse association for leptin (HR = 0.44, 95% CI: 0.29-0.68) within the first year of blood draw, whereas the association for IL-6 remained statistically significant over 10 years.<bold>Conclusion: </bold>Our results support the role of chronic inflammation in CRC progression and suggested several post-treatment inflammatory biomarkers, particularly IL-6, are promising prognostic markers for stage II-III CRC patients.
- Subjects
C-reactive protein; INTERLEUKINS; DISEASE progression; RESEARCH; LEPTIN; RESEARCH methodology; PROGNOSIS; CASE-control method; MEDICAL cooperation; EVALUATION research; COLORECTAL cancer; TUMOR classification; COMPARATIVE studies; ADIPONECTIN; SURVIVAL analysis (Biometry); RESEARCH funding; INFLAMMATORY mediators
- Publication
British Journal of Cancer, 2021, Vol 125, Issue 6, p806
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/s41416-021-01458-y