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- Title
New loci associated with kidney function and chronic kidney disease.
- Authors
Köttgen, Anna; Pattaro, Cristian; Böger, Carsten A.; Fuchsberger, Christian; Olden, Matthias; Glazer, Nicole L.; Parsa, Afshin; Xiaoyi Gao; Qiong Yang; Smith, Albert V.; O'Connell, Jeffrey R.; Man Li; Schmidt, Helena; Tanaka, Toshiko; Isaacs, Aaron; Ketkar, Shamika; Shih-Jen Hwang; Johnson, Andrew D.; Dehghan, Abbas; Teumer, Alexander
- Abstract
Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m2; n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide–significant loci (P < 5 × 10−8) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.
- Subjects
LOCUS (Genetics); KIDNEY diseases; FOCAL segmental glomerulosclerosis; NEOVASCULARIZATION; BLOOD-vessel development; META-analysis; GENE therapy; GENETICS
- Publication
Nature Genetics, 2010, Vol 42, Issue 5, p376
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.568