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- Title
Research Highlights.
- Authors
Axton, Myles; Niemitz, Emily; Packer, Alan; Vogan, Kyle
- Abstract
The article presents information on several researches which take place in the field of medicine. Researcher Elissa Epel and colleagues found that mothers caring for a chronically ill child had telomeres as short as those of mothers a decade older with a healthy child. The lengths of the telomeres and caregiving period were negatively correlated. Caregiving is stressful; this was measured both in a questionnaire reporting subjective experience and by the ratio of objective markers of oxidative stress in urine to vitamin E in peripheral blood mononuclear cells. The cytochrome P450 (CYP) genes have important roles in the metabolism of a variety of endogenous substrates as well as prescription drugs. One key factor in regulating CYP expression is the CYP3A5 intron 3 polymorphism, which results in the production of a nonfunctional protein. The frequency of this nonexpressor variant varies between different populations, and researcher E.E. Thompson and colleagues now show that this variation correlates with distance from the equator.
- Subjects
MOTHERS; TELOMERES; CHROMOSOMES; OXIDATIVE stress; METABOLISM; CYTOCHROMES; VITAMIN E
- Publication
Nature Genetics, 2005, Vol 37, Issue 1, p17
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng0105-17