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- Title
Italian Association of Clinical Endocrinologists (AME) and International Chapter of Clinical Endocrinology (ICCE). Position statement for clinical practice: prolactin-secreting tumors.
- Authors
Cozzi, Renato; Ambrosio, Maria Rosaria; Attanasio, Roberto; Battista, Claudia; Bozzao, Alessandro; Caputo, Marco; Ciccarelli, Enrica; De Marinis, Laura; De Menis, Ernesto; Fustini, Marco Faustini; Grimaldi, Franco; Lania, Andrea; Lasio, Giovanni; Logoluso, Francesco; Losa, Marco; Maffei, Pietro; Milani, Davide; Poggi, Maurizio; Zini, Michele; Katznelson, Laurence
- Abstract
Prolactinomas are the most frequent pituitary adenomas. Prolact inoma may occur in different clinical settings and always require an individually tailored approach. This is the r eason why a panel of Italian neuroendocrine experts was charged with the task to provide indications for the diagnostic and therapeutic approaches that can be easily applied in different contexts. The document provides 15 recommen dations for diagnosis and 54 recommendations for treatment, issued according to the GRADE system. The level of agreement among panel members was formally evaluated by RAND-UCLA methodology. In the last century, prolac tinomas represented the paradigm of pituitary tumors for which the development of highly effective drugs obtai ned the best results, allowing to avoid neurosurgery in most cases. The impressive improvement of neurosurgical endo scopic techniques allows a far better definition of the tumoral tissue during surgery and the remission of endocrine symptoms in many patients with pituitary tumors. Consequently, this refinement of neurosurgery is changing the th erapeutic strategy in prolactinomas, allowing the definitive cure of some patients with permanent discontinuation of medical therapy.
- Subjects
ENDOCRINE diseases; PROLACTINOMA; PITUITARY tumors; ENDOCRINOLOGISTS; THERAPEUTICS; TUMORS
- Publication
European Journal of Endocrinology, 2022, Vol 186, Issue 3, pP1
- ISSN
0804-4643
- Publication type
Article
- DOI
10.1530/EJE-21-0977