We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The SLC16A11 risk haplotype is associated with decreased insulin action, higher transaminases and large-size adipocytes.
- Authors
Almeda-Valdes, Paloma; Gómez Velasco, Donaji V.; Campos, Olimpia Arellano; Bello-Chavolla, Omar Yaxmehen; del Rocío Sevilla-González, Magdalena; Ruiz, Tannia Viveros; Martagón Rosado, Alexandro J.; Bautista, Claudia J.; Hernandez, Liliana Muñoz; Cruz-Bautista, Ivette; Moreno-Macias, Hortensia; Huerta-Chagoya, Alicia; Rodríguez-Álvarez, Karen Guadalupe; Walford, Geoffrey A.; Jacobs, Suzanne B. R.; Guillen Pineda, Luz E.; Ordoñez-Sánchez, Ma Luisa; Roldan-Valadez, Ernesto; Azpiroz, Joaquín; Furuzawa-Carballeda, Jannette
- Abstract
Objective: A haplotype at chromosome 17p13 that reduces expression and function of the solute carrier transporter SLC16A11 is associated with increased risk for type 2 diabetes in Mexicans. We aim to investigate the detailed metabolic profile of SLC16A11 risk haplotype carriers to identify potential physiological mechanisms explaining the increased type 2 diabetes risk. Design: Cross-sectional study. Methods: We evaluated carriers (n = 72) and non-carriers (n = 75) of the SLC16A11 risk haplotype, with or without type 2 diabetes. An independent sample of 1069 subjects was used to re plicate biochemical findings. The evaluation included euglycemic-hyperinsulinemic clamp, frequently sampled intravenous glucose tolerance test (FSIVGTT), dual-energy X-ray absorptiometry (DXA), MRI and spectroscopy and subcutaneous abdominal adipose tissue biopsies. Results: Fat-free mass (FFM)-adjusted M value was lower in carriers of the SLC16A11 risk haplotype after adjusting for age and type 2 diabetes status (β = −0.164, P = 0.04). Subjects with type 2 diabetes and the risk haplotype demonstrated an increase of 8.76 U/L in alanine aminotransferas e (ALT) (P = 0.02) and of 7.34 U/L in gammaglutamyltransferase (GGT) (P = 0.05) compared with non-carriers and after adjusting for gende r, age and ancestry. Among women with the risk haplotype and normal BMI, the adipocyte size was higher (P < 0.001). Conclusions: Individuals carrying the SLC16A11 risk haplotype exhibited decreased insulin action. Higher serum ALT and GGT levels were found in carriers with type 2 diabetes, and larger adipocytes in subcutaneous fat in the size distribution in carrier women with normal weight.
- Subjects
ABDOMINAL adipose tissue; DUAL-energy X-ray absorptiometry; TYPE 2 diabetes; FAT cells; GLUCOSE tolerance tests
- Publication
European Journal of Endocrinology, 2019, Vol 180, Issue 2, p99
- ISSN
0804-4643
- Publication type
Article
- DOI
10.1530/EJE-18-0677